Description

3,5-Difluorobenzeneboronic Acid Neopentyl Glycol Cyclic Ester is a high-purity, protected boronic acid derivative designed for advanced synthetic chemistry. This compound is a critical building block in cross-coupling reactions, offering enhanced stability and handling characteristics compared to its free boronic acid counterpart. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-quality intermediates for constructing complex fluorinated aromatic structures.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), especially those containing difluorophenyl motifs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the introduction of a fluorinated benzene ring is required for bioactivity.
• Liquid Crystal & OLED Materials: Serves as a building block for creating fluorinated organic semiconductors and liquid crystal compounds used in electronic displays.
• Polymer & Resin Modification: Employed to introduce boronate ester functional groups into polymer chains for specialty materials with unique properties.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new synthetic pathways and creating compound libraries.
• Fluorinated Ligand Synthesis: Used in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	3,5-Difluorobenzeneboronic Acid Neopentyl Glycol Cyclic Ester
CAS No.	216393-57-6
Molecular Formula	C₁₃H₁₇BF₂O₂
Molecular Weight	254.08 g/mol
Synonyms	3,5-Difluorophenylboronic Acid Neopentyl Glycol Ester; 2-(3,5-Difluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane; 3,5-Difluorobenzeneboronic Acid Pinned Ester; 3,5-Difluorophenylboronic Acid Pinned Ester; 3,5-Difluorophenyl-1,3,2-dioxaborinane, 5,5-dimethyl-2-(3,5-difluorophenyl)-; Neopentyl Glycol (3,5-Difluorophenyl)boronate; B-(3,5-Difluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane
EINECS	Contact for details

Quality Control

Our 3,5-Difluorobenzeneboronic Acid Neopentyl Glycol Cyclic Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent hydrolysis and maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.