Description

Phosphine, [(1S,4S)-1,4-Dimethyl-1,4-Butanediyl]Bis[Diphenyl- (9Ci) is a specialized organophosphorus compound featuring a chiral, bidentate phosphine ligand structure. This compound matters for its role as a sophisticated ligand in asymmetric catalysis, enabling the synthesis of high-value, enantiomerically pure intermediates. Pharmaceutical R&D laboratories and fine chemical manufacturers need it to develop novel active pharmaceutical ingredients (APIs) and advanced materials where precise stereochemical control is critical. CAS No. 216019-41-9.

Application

• As a chiral ligand in asymmetric hydrogenation and cross-coupling reactions for pharmaceutical synthesis.
• Catalyst component in the production of enantiomerically pure fine chemicals and agrochemical intermediates.
• Research and development of novel transition metal catalysts for academic and industrial applications.
• Key reagent in methodology development for stereoselective organic transformations.
• Potential use in material science for creating chiral polymeric or coordination complexes.

Basic Information

Product Name	Phosphine, [(1S,4S)-1,4-Dimethyl-1,4-Butanediyl]Bis[Diphenyl- (9Ci)
CAS No.	216019-41-9
Molecular Formula	C32H34P2
Molecular Weight	480.56 g/mol
Synonyms	(1S,4S)-2,5-Dimethyl-1,4-bis(diphenylphosphino)butane; (S,S)-Me-DuPhos; (S,S)-1,2-Bis(2,5-dimethylphospholano)benzene (precursor related); (S,S)-2,5-Dimethyl-1,4-bis(diphenylphosphino)butane; (S,S)-Dimethyl-BuPhos; DuPhos ligand derivative; Chiral bidentate phosphine ligand; Me-DuPhos
EINECS	Contact for details

Quality Control

Our high-purity chiral phosphine ligands are produced under strict quality control protocols to ensure batch-to-batch consistency and optimal catalytic performance. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and chiral analysis to confirm chemical identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. This compound is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.