Description

1,2-Bis(Di-tert-Butylphosphino)Benzene is a highly specialized, sterically hindered bidentate phosphine ligand. This compound matters for its exceptional electron-donating properties and robust steric bulk, which are critical for stabilizing reactive metal centers and enabling challenging catalytic transformations. It is primarily needed by researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries for advanced cross-coupling and hydrogenation reactions.

Application

• Homogeneous Catalysis: As a key ligand in palladium- and nickel-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Negishi) for complex molecule synthesis.
• Pharmaceutical Intermediates: Enabling the synthesis of active pharmaceutical ingredients (APIs) requiring high selectivity and yield under mild conditions.
• Agrochemical Synthesis: Used in the catalytic production of advanced herbicides, fungicides, and insecticides.
• Material Science Research: For the development of novel organometallic complexes and catalysts in academic and industrial R&D.
• Hydrogenation Catalysis: Facilitating selective reduction reactions in fine chemical and fragrance manufacturing.
• Asymmetric Synthesis: Potential use in creating chiral ligands for enantioselective catalytic processes.

Basic Information

Product Name	1,2-Bis(Di-tert-Butylphosphino)Benzene
CAS No.	215951-98-7
Molecular Formula	C22H40P2
Molecular Weight	366.50 g/mol
Synonyms	1,2-Bis(di-tert-butylphosphino)benzene; DtBPP; Di-tert-butylphosphinobenzene; 1,2-Bis(di-tert-butylphosphanyl)benzene; 1,2-Bis[bis(1,1-dimethylethyl)phosphino]benzene; 1,2-Bis[bis(tert-butyl)phosphino]benzene; Benzene, 1,2-bis[bis(1,1-dimethylethyl)phosphino]-; (o-Phenylenebis(di-tert-butylphosphine))
EINECS	Contact for details

Quality Control

Our 1,2-Bis(Di-tert-Butylphosphino)Benzene is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity for sensitive catalytic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality system is designed to meet the stringent requirements of pharmaceutical and advanced R&D customers.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C or as specified on the label. This material is easily oxidized (store under inert atmosphere). Keep away from heat and incompatible materials. Allow the sealed container to reach ambient temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.