Description

2-Fluoro-4-(Hydroxymethyl)Benzoic Acid is a versatile fluorinated benzoic acid derivative that serves as a critical building block in advanced organic synthesis. Its bifunctional structure, featuring both a carboxylic acid and a hydroxymethyl group on a fluorinated aromatic ring, makes it a valuable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Key starting material or building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drug candidates.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and pesticides where the fluorine atom enhances biological activity and stability.
• Liquid Crystal & OLED Material Precursor: Serves as a monomer or intermediate in the synthesis of fluorinated aromatic compounds for electronic display materials.
• Polymer Modification: Employed to introduce fluorinated benzoic acid groups into polymer chains to alter thermal stability, solubility, or surface properties.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new fluorination chemistry and creating novel molecular architectures.
• Peptide & Conjugate Synthesis: The carboxylic acid group allows for coupling reactions, useful in creating peptide conjugates or labeled compounds for biochemical studies.

Basic Information

Product Name	2-Fluoro-4-(Hydroxymethyl)Benzoic Acid
CAS No.	214554-18-4
Molecular Formula	C8H7FO3
Molecular Weight	170.14 g/mol
Synonyms	4-(Hydroxymethyl)-2-fluorobenzoic Acid; 2-Fluoro-4-(hydroxymethyl)benzoic acid; Benzoic acid, 2-fluoro-4-(hydroxymethyl)-; 2-Fluoro-4-carboxymethylbenzoic Acid (common misnomer); 2-Fluoro-4-(hydroxymethyl)benzoate (anion form); 2-F-4-HMBA; F-HMBA
EINECS	Contact for details

Quality Control

Our production of 2-Fluoro-4-(Hydroxymethyl)Benzoic Acid adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.