Description

3-Fluoro-4-(Hydroxymethyl)Benzoic Acid is a versatile fluorinated benzoic acid derivative that serves as a critical building block in advanced organic synthesis. Its bifunctional structure, featuring both a carboxylic acid and a hydroxymethyl group on a fluorinated aromatic ring, makes it a valuable intermediate for constructing complex molecules with tailored properties. This compound is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical, agrochemical, and material science sectors for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and plant growth regulators, where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated monomers and polymers used in electronic displays and organic light-emitting diodes (OLEDs).
• Peptide & Linker Chemistry: The carboxylic acid and hydroxymethyl groups facilitate its use in solid-phase peptide synthesis (SPPS) and as a linker or spacer molecule in bioconjugation.
• Metal-Organic Framework (MOF) Construction: Acts as a functionalized organic linker for creating novel porous coordination polymers with specific adsorption or catalytic properties.
• Fluorinated Polymer Research: Employed as a monomer or modifier in the synthesis of specialty polymers to impart unique chemical resistance, surface properties, or optical characteristics.

Basic Information

Product Name	3-Fluoro-4-(Hydroxymethyl)Benzoic Acid
CAS No.	214554-16-2
Molecular Formula	C8H7FO3
Molecular Weight	170.14 g/mol
Synonyms	4-(Hydroxymethyl)-3-fluorobenzoic Acid; 3-Fluoro-4-(hydroxymethyl)benzoic acid; Benzoic acid, 3-fluoro-4-(hydroxymethyl)-; 3-Fluoro-4-carboxymethylbenzoic Acid (common misnomer); 3-Fluoro-4-(hydroxymethyl)benzoate (deprotonated form); F-4-HMBA; 214554-16-2 (CAS Registry Number)
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-(Hydroxymethyl)Benzoic Acid is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and process development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.