Description

Methyl 2-Trifluoromethylbenzoylacetate is a high-value fluorinated organic building block, specifically a β-ketoester derivative, essential for advanced synthetic chemistry. Its core value lies in the trifluoromethyl group, which imparts unique electronic and metabolic properties to target molecules, making it indispensable for creating compounds with enhanced biological activity and stability. This intermediate is critically needed by R&D and process development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring a trifluoromethylphenyl moiety for improved lipophilicity and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides where the CF3 group enhances pesticidal activity and environmental persistence.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers with tailored optical or electronic properties.
• Ligand and Catalyst Development: Employed in organic synthesis for constructing complex, fluorinated ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: A versatile starting material for academic and industrial research exploring new C-C and C-F bond-forming reactions.

Basic Information

Product Name	Methyl 2-Trifluoromethylbenzoylacetate
CAS No.	212755-77-6
Molecular Formula	C11H9F3O3
Molecular Weight	246.18 g/mol
Synonyms	Methyl 3-oxo-3-[2-(trifluoromethyl)phenyl]propanoate; 2-Trifluoromethylbenzoylacetic Acid Methyl Ester; 3-Oxo-3-(2-trifluoromethylphenyl)propionic Acid Methyl Ester; Methyl (2-Trifluoromethylbenzoyl)acetate; 3-(2-Trifluoromethylphenyl)-3-oxopropanoic Acid Methyl Ester; Acetic acid, 2-(trifluoromethyl)benzoyl-, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 2-Trifluoromethylbenzoylacetate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure high chemical purity and consistency, meeting the stringent requirements for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible materials. The container must be kept tightly closed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.