Description

1-o-Hexadecyl-(7,7,8,8-D4)-2-o-Acetyl-Sn-Glyceryl-3-Phosphorylcholine is a deuterated analog of a key phospholipid, specifically designed for advanced research and analytical applications. This compound is critical for use as an internal standard in mass spectrometry, enabling precise quantification and metabolic tracing in lipidomics studies. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and academic institutions focused on lipid biochemistry, drug delivery systems, and biomarker discovery.

Application

• Internal Standard for Lipidomics: Essential for the accurate quantification of phosphatidylcholine species in complex biological samples via LC-MS/MS.
• Metabolic Pathway Tracing: Used in deuterium-labeling studies to investigate phospholipid metabolism, biosynthesis, and turnover.
• Pharmaceutical R&D: Supports drug development research focused on lipid-based drug delivery systems, such as liposomes and lipid nanoparticles (LNPs).
• Biomarker Research: Aids in the discovery and validation of lipid biomarkers for various disease states.
• Membrane Biophysics: Employed in studies of model membrane systems to understand lipid-lipid and lipid-protein interactions without isotopic interference.
• Quality Control Reference: Serves as a certified reference material (CRM) for ensuring the accuracy and precision of analytical methods in contract research organizations (CROs).

Basic Information

Item	Detail
Product Name	1-o-Hexadecyl-(7,7,8,8-D4)-2-o-Acetyl-Sn-Glyceryl-3-Phosphorylcholine
CAS No.	211106-54-6
Molecular Formula	C26H49D4NO7P
Molecular Weight	Approx. 534.7 g/mol
Synonyms	1-Hexadecyl-2-acetyl-sn-glycero-3-phosphocholine (d4); Deuterated PAF C-16 (d4); 1-O-Hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine-d4; Lyso-PAF C-16 Acetate-d4; Platelet-Activating Factor C-16-d4; 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine (d4, 7,7,8,8); sn-Glycero-3-phosphocholine derivative-d4
EINECS	Contact for details

Quality Control

Every batch of 1-o-Hexadecyl-(7,7,8,8-D4)-2-o-Acetyl-Sn-Glyceryl-3-Phosphorylcholine is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive characterization by NMR, MS, and HPLC. A detailed Certificate of Analysis (COA), providing batch-specific data on purity, isotopic enrichment, and impurities, is supplied with each order to ensure traceability and compliance with your research protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (Titration)	≥ 97%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.