Description

8-Epi Pgf2Alpha-D4 is a deuterium-labeled analog of the prostaglandin F2α metabolite, 8-epi-prostaglandin F2α, serving as a critical internal standard for precise quantitative analysis. This high-purity, isotopically labeled compound is essential for ensuring accuracy and reliability in advanced mass spectrometry-based assays. It is primarily utilized by researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors for biomarker research, method validation, and pharmacokinetic studies.

Application

• Internal Standard for LC-MS/MS: Essential for the accurate quantification of 8-epi-prostaglandin F2α, a biomarker of oxidative stress, in complex biological matrices like plasma, urine, and tissue homogenates.
• Biomarker Research & Validation: Used in method development and validation for studying oxidative stress pathways, inflammation, and related disease states in preclinical and clinical research.
• Pharmaceutical R&D: Supports drug metabolism and pharmacokinetic (DMPK) studies for compounds targeting inflammatory or oxidative pathways.
• Clinical Diagnostics: Enables the standardization of assays measuring isoprostanes for diagnostic and prognostic evaluation in cardiovascular, neurological, and metabolic disorders.
• Reference Material: Serves as a certified reference material (CRM) for calibrating analytical instruments and ensuring regulatory compliance in GLP/GMP environments.

Basic Information

Product Name	8-Epi Pgf2Alpha-D4
CAS No.	211105-40-7
Molecular Formula	C₂₀H₃₂D₄O₅
Molecular Weight	356.50 g/mol
Synonyms	8-epi-Prostaglandin F2α-d4; 8-iso-PGF2α-d4; 15-F2t-IsoP-d4; (5Z,9α,11α,13E,15S)-9,11,15-Trihydroxyprosta-5,13-dien-1-oic-3,3,4,4-d4 Acid; Deuterated 8-epi-PGF2α; 8-epi-PGF2α Internal Standard; 8-iso-Prostaglandin F2α-d4; 15-F2t-Isoprostane-d4
EINECS	Contact for details

Quality Control

Every batch of 8-Epi Pgf2Alpha-D4 is manufactured and analyzed under strict quality systems to ensure the highest standards of purity and isotopic enrichment. Our products undergo rigorous quality testing, including NMR and mass spectrometry, to confirm chemical structure, deuterium incorporation, and purity, ensuring compliance with research and analytical standards. A comprehensive Certificate of Analysis (COA) detailing batch-specific results for purity, isotopic purity, and identity is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize exposure to moisture. The product is highly volatile and light-sensitive; handle with appropriate precautions in a well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (MS)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in ethanol, acetonitrile; slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.