Description

Edonentan CAS NO 210891-04-6 is a potent and selective endothelin A (ETA) receptor antagonist. This compound is of significant value in pharmaceutical research and development, particularly for investigating cardiovascular and pulmonary disease pathways. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery of novel therapeutics targeting endothelin-mediated conditions.

Application

• Pharmaceutical Research: A key reference standard and active pharmaceutical ingredient (API) intermediate in the development of endothelin receptor antagonist drugs.
• Cardiovascular Disease Studies: Used in preclinical research to study the role of endothelin in conditions such as hypertension, pulmonary arterial hypertension (PAH), and heart failure.
• Biochemical Assay Development: Serves as a critical tool compound for validating high-throughput screening assays and studying ETA receptor binding kinetics.
• Academic Research: Employed in university and institutional labs for fundamental pharmacological studies on the endothelin system.
• Process Chemistry: Used as a building block or intermediate in the synthetic scale-up and optimization of related therapeutic candidates.

Basic Information

Product Name	Edonentan
CAS No.	210891-04-6
Molecular Formula	C29H41N3O6S
Molecular Weight	559.72 g/mol
Synonyms	5-(Dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide; BSF 208075; J-104132; LU 135252; Edonentan Hydrochloride; Edonentan HCl; A selective ETA receptor antagonist
EINECS	Contact for details

Quality Control

Our Edonentan is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and MS, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator after opening to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.