Description

3-[(R)-2-(N,n-Dimethylamino)Ethylthio-Sar]-4-(3-Hydroxymethylleucine)Cyclosporin is a chemically modified derivative of the potent immunosuppressive agent Cyclosporin A, designed for advanced research and development applications. This compound is of significant interest for its potential to modulate the pharmacokinetic and pharmacodynamic properties of the parent molecule, offering researchers a valuable tool for probing biological pathways and developing novel therapeutics. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on immunology, transplant medicine, and autoimmune disease research.

Application

• Pharmaceutical Research & Development: As a key intermediate or reference standard in the synthesis and study of novel immunosuppressive agents and prodrugs.
• Immunology Studies: For investigating structure-activity relationships (SAR) of cyclosporine analogs and their interaction with cellular targets like cyclophilin.
• Prodrug Development: Serving as a model compound in the design of prodrugs aimed at improving solubility, bioavailability, or targeted delivery of immunosuppressive therapies.
• Biochemical Assays: Used as a specialized reagent in enzymatic and binding assays to study calcineurin inhibition and T-cell activation pathways.
• Process Chemistry & Scale-up: Employed as a critical building block during the optimization and scale-up of synthetic routes for complex peptide-based pharmaceuticals.
• Quality Control & Analytical Standards: Functioning as a high-purity certified reference material (CRM) for HPLC, LC-MS, or NMR analysis in quality assurance laboratories.

Basic Information

Product Name	3-[(R)-2-(N,n-Dimethylamino)Ethylthio-Sar]-4-(3-Hydroxymethylleucine)Cyclosporin
CAS No.	210759-10-7
Molecular Formula	C65H117N11O12S
Molecular Weight	1260.75 g/mol
Synonyms	Cyclosporin A Derivative; [3-[(R)-2-(Dimethylamino)ethylthio-Sar]-4-(3-hydroxymethylleucine)]-Cyclosporin; Modified Cyclosporine Analog; CsA-Derivative 210759-10-7; (3R)-3-[[(2R)-2-[[(2S,3R,4R)-3-Hydroxy-4-methyl-2-(methylamino)oct-6-enoyl]amino]-3-methylbutanoyl]amino]-4-[[(2S)-2-(dimethylamino)ethylsulfanyl]-N,3-dimethylbutanoyl]-2-[(2S,3S,6S)-3-hydroxy-1-methyl-4,6-dimethyl-5-oxo-2,7-diazabicyclo[4.3.0]nonan-8-yl]-6-methylheptanamide
EINECS	Contact for details

Quality Control

Our 3-[(R)-2-(N,n-Dimethylamino)Ethylthio-Sar]-4-(3-Hydroxymethylleucine)Cyclosporin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization using techniques including HPLC, MS, and NMR to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical specifications. We support research and development with materials produced to meet the exacting standards required for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This compound is hygroscopic (moisture-sensitive); the container should be sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to prevent degradation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.