Description

Sitaxentan Sodium is a high-purity, non-peptide endothelin receptor antagonist. This compound is a critical pharmaceutical intermediate and reference standard for research and development. It is primarily utilized in the synthesis of active pharmaceutical ingredients (APIs) and for investigative studies in cardiovascular and pulmonary research. Global pharmaceutical manufacturers and advanced research institutions rely on this material for its consistent quality and precise biological activity.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of endothelin receptor antagonist APIs.
• Reference Standard: Used for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Biochemical Research: A vital tool for in-vitro and in-vivo studies targeting the endothelin system in cardiovascular and pulmonary diseases.
• Preclinical Development: Employed in pharmacological and toxicological studies during drug discovery pipelines.
• Formulation Development: Used in stability studies and excipient compatibility testing for new drug formulations.

Basic Information

Product Name	Sitaxentan Sodium
CAS No.	210421-74-2
Molecular Formula	C18H14N2O6S2•Na
Molecular Weight	441.43 g/mol
Synonyms	Sitaxsentan Sodium; TBC-11251 Sodium; (+)-Sitaxsentan Sodium; Sodium 5-(Dimethylamino)-N-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide; N-(3,4-Dimethyl-5-isoxazolyl)-5-(dimethylamino)-1-naphthalenesulfonamide Sodium Salt; 1-Naphthalenesulfonamide, N-(3,4-dimethyl-5-isoxazolyl)-5-(dimethylamino)-, sodium salt (1:1)
EINECS	Contact for details

Quality Control

Our Sitaxentan Sodium is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation (IR, NMR) to ensure it meets exacting standards for pharmaceutical research and development. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.