Description

Estradiol 17-Octadecanoate-1-14C is a carbon-14 labeled derivative of estradiol stearate, a long-chain fatty acid ester of the natural estrogen. This radiolabeled compound is a critical tool for metabolic and pharmacokinetic studies, enabling precise tracking and quantification in biological systems. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and academic sectors for advanced tracer studies, drug metabolism and disposition (DMD) research, and analytical method development.

Application

• Tracer Studies in Drug Metabolism Research: Used to elucidate the absorption, distribution, metabolism, and excretion (ADME) pathways of estradiol-based compounds.
• Pharmacokinetic Modeling: Enables accurate quantification of drug concentrations in plasma, tissues, and excreta for modeling purposes.
• Analytical Method Development and Validation: Serves as an internal standard or reference material in LC-MS/MS, HPLC, and other chromatographic assays.
• Endocrine Disruptor Research: Applied in environmental and toxicological studies to investigate the fate and behavior of estrogenic compounds.
• Bioconjugation and Prodrug Studies: Acts as a labeled precursor for studying the hydrolysis and activation of esterified hormone prodrugs.

Basic Information

Product Name	Estradiol 17-Octadecanoate-1-14C
CAS No.	210241-63-7
Molecular Formula	C36H60O3 (with 14C label at the 1-position of the octadecanoate chain)
Molecular Weight	~540.9 g/mol (unlabeled)
Synonyms	Estradiol 3-Benzolate 17-Stearate-1-14C; [1-14C]Stearic Acid Estradiol Ester; 17β-Estradiol 17-Octadecanoate-1-14C; Estradiol Stearate-1-14C; Estrone-17β-(3-benzoyl)-17α-stearate-1-14C; Oestradiol 17-Octadecanoate-1-14C; 14C-Labeled Estradiol Stearate
EINECS	Contact for details

Quality Control

Every batch of Estradiol 17-Octadecanoate-1-14C is manufactured and analyzed under strict quality systems to ensure identity, purity, and specific activity. Our products undergo rigorous quality testing to ensure compliance with industry standards for radiolabeled compounds. Certificates of Analysis (COA) detailing specific activity, radiochemical purity (typically >97% by HPLC), chemical purity, and solvent content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, dry environment to maintain stability. Allow the vial to warm to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR / NMR)	Conforms to structure
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Chemical Purity (HPLC)	≥ 95%
Solvent Content (Residual Solvents)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.