Description

D-[1,2-13C2]Ribose is a stable isotope-labeled analog of the essential pentose sugar, D-ribose, specifically enriched with carbon-13 at the 1 and 2 positions. This precise isotopic labeling makes it an indispensable tool for advanced metabolic research and analytical method development, providing unparalleled traceability and accuracy. It is primarily required by research institutions, pharmaceutical developers, and diagnostic companies engaged in nucleic acid research, metabolic flux analysis (MFA), and the synthesis of isotopically labeled biomarkers or pharmaceuticals.

Application

• Metabolic Pathway Tracing: Used as a tracer in in vitro and in vivo studies to elucidate the pentose phosphate pathway and nucleotide biosynthesis routes via Nuclear Magnetic Resonance (NMR) or Mass Spectrometry (MS).
• Stable Isotope-Labeled Standard (SILS): Serves as an internal standard for the precise quantification of ribose and its metabolites in complex biological matrices using LC-MS or GC-MS, ensuring high accuracy and reproducibility.
• Pharmaceutical Research & Development: A key building block for the synthesis of isotopically labeled nucleosides, nucleotides, and mRNA vaccines for pharmacokinetic and drug metabolism studies.
• Diagnostic Agent Development: Employed in the creation of novel probes and agents for advanced medical imaging techniques like hyperpolarized 13C MRI.
• Biochemical Research: Fundamental research into enzyme mechanisms (kinetics, binding studies) and carbohydrate chemistry where positional isotopic enrichment is critical.
• Quality Control & Method Validation: Used in analytical laboratories to validate and calibrate instruments and methods for sugar analysis.

Basic Information

Product Name	D-[1,2-13C2]Ribose
CAS No.	209909-88-6
Molecular Formula	C3¹³C2H10O5
Molecular Weight	152.10 g/mol (for ¹³C2 labeled form)
Synonyms	D-Ribose-1,2-¹³C₂; (2R,3R,4R)-2,3,4,5-Tetrahydroxypentanal-1,2-¹³C₂; ¹³C2-D-Ribose; Ribose-1,2-13C2; Isotopically labeled D-ribose; D-Ribose (1,2-13C2); Stable isotope labeled ribose; D-(-)-Ribose-1,2-13C2
EINECS	Contact for details

Quality Control

Our D-[1,2-13C2]Ribose is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical purity, isotopic enrichment, and chiral integrity. Certificates of Analysis (COA) are provided, detailing results for assay (HPLC), isotopic enrichment (NMR/MS), optical rotation, residual solvent analysis, and other relevant parameters. We support research requiring compliance with various pharmacopeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation by absorption of atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % ¹³C at positions 1 & 2
Optical Rotation	-20.0° to -23.0° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Specific Optical Rotation	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.