Description

2,3-Difluoromandelic Acid is a fluorinated derivative of mandelic acid, serving as a key chiral building block and intermediate in advanced organic synthesis. Its value lies in the unique reactivity imparted by the fluorine atoms at the 2 and 3 positions, which can significantly influence the biological activity and physicochemical properties of target molecules. This compound is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing new active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of novel fluorinated drug candidates, particularly in central nervous system (CNS) and anti-inflammatory therapeutic areas.
• Agrochemical Research: Used in developing advanced, fluorinated pesticides and herbicides where the fluorine atoms enhance metabolic stability and bioavailability.
• Ligand and Catalyst Preparation: Serves as a precursor for chiral ligands used in asymmetric catalysis, enabling the production of enantiomerically pure compounds.
• Material Science: Employed in the research of specialty polymers and liquid crystals, where fluorinated aromatic compounds modify material properties.
• Academic & Industrial R&D: A valuable reagent for methodological studies in organic chemistry, exploring new fluorination and coupling reactions.

Basic Information

Product Name	2,3-Difluoromandelic Acid
CAS No.	207974-19-4
Molecular Formula	C8H6F2O3
Molecular Weight	188.13 g/mol
Synonyms	(2,3-Difluorophenyl)(hydroxy)acetic acid; α-Hydroxy-2,3-difluorobenzeneacetic acid; DL-2,3-Difluoromandelic Acid; 2,3-Difluorophenylglycolic acid; (±)-2,3-Difluoromandelic acid; 2,3-DFMA; Mandelic acid, 2,3-difluoro-
EINECS	Contact for details

Quality Control

Our 2,3-Difluoromandelic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for research and production. Certificates of Analysis (COA) detailing all specifications are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Due to its acidic nature, keep away from strong bases and oxidizing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	Racemic mixture (DL-Form)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.