Description

Tenofovir Diphosphate is the active diphosphate metabolite of the antiviral prodrug tenofovir. This compound is a critical nucleotide analog that directly inhibits viral replication by acting as a chain terminator. It is an essential reference standard and active pharmaceutical ingredient (API) intermediate for research, development, and quality control in the pharmaceutical industry, particularly for antiviral therapies targeting HIV and hepatitis B.

Application

• Pharmaceutical Reference Standard: Used as a high-purity certified standard for analytical testing, method validation, and quality control of antiviral drug products and APIs.
• Active Pharmaceutical Ingredient (API) Intermediate: A key synthetic precursor in the manufacturing of tenofovir-based antiviral medications.
• Biochemical Research: Employed in virology and pharmacology studies to investigate the mechanism of action, efficacy, and resistance profiles of nucleotide reverse transcriptase inhibitors.
• In-Vitro Diagnostics (IVD): Utilized in the development and calibration of diagnostic assays for monitoring antiviral drug levels or studying metabolic pathways.
• Academic and Contract Research: Serves as a vital reagent for universities and CROs conducting pre-clinical and clinical research on antiviral agents.

Basic Information

Product Name	Tenofovir Diphosphate
CAS No.	206646-04-0
Molecular Formula	C9H14N5O10P3
Molecular Weight	447.15 g/mol
Synonyms	Tenofovir Diphosphate; PMPA Diphosphate; (R)-9-(2-Phosphonomethoxypropyl)adenine Diphosphate; (R)-PMPA Diphosphate; GS 4331-05 Diphosphate; TDF-DP; Bis(POC)PMPA Diphosphate (related prodrug metabolite); Tenofovir PP
EINECS	Contact for details

Quality Control

Our Tenofovir Diphosphate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. We provide Certificates of Analysis (COA) with detailed chromatograms and full traceability. Our quality commitment aligns with cGMP guidelines for pharmaceutical intermediates, ensuring reliability for your critical research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccants or an inert atmosphere to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.