Description

9-[(R)-2-(Phosphonomethoxy)Propyl]Adenine Monohydrate is a high-purity nucleoside phosphonate analog, a key intermediate in antiviral research and pharmaceutical synthesis. Its primary commercial value lies in its role as a precursor to Tenofovir, a critical active pharmaceutical ingredient (API) used in antiviral medications. This compound is essential for pharmaceutical manufacturers, research institutions, and CDMOs (Contract Development and Manufacturing Organizations) focused on developing and producing treatments for viral infections.

Application

• Pharmaceutical Intermediate: Primary use as a key chiral building block in the synthesis of Tenofovir and its prodrugs (e.g., Tenofovir Disoproxil Fumarate).
• Antiviral API Synthesis: Critical raw material in the manufacturing chain for antiviral Active Pharmaceutical Ingredients (APIs) targeting HIV and Hepatitis B.
• Biochemical Research: Used in life science research to study nucleotide metabolism, viral polymerase inhibition mechanisms, and structure-activity relationships (SAR).
• Process Development: Serves as a reference standard and starting material for process chemistry optimization and scale-up in GMP environments.
• Contract Manufacturing: Supplied to CDMOs for the production of finished dosage forms under strict regulatory compliance (e.g., FDA, EMA).

Basic Information

Product Name	9-[(R)-2-(Phosphonomethoxy)Propyl]Adenine Monohydrate
CAS No.	206184-49-8
Molecular Formula	C9H14N5O4P • H2O
Molecular Weight	305.23 g/mol (Anhydrous basis: 287.21 g/mol)
Synonyms	(R)-PMPA Monohydrate; (R)-9-[2-(Phosphonomethoxy)propyl]adenine Monohydrate; (R)-GS-1278 Monohydrate; Tenofovir Intermediate; (R)-HPMPA Derivative; (R)-[[2-(6-Amino-9H-purin-9-yl)-1-methylethoxy]methyl]phosphonic Acid Monohydrate; Adefovir Related Compound
EINECS	Contact for details

Quality Control

Our 9-[(R)-2-(Phosphonomethoxy)Propyl]Adenine Monohydrate is manufactured under strict quality management systems. We provide material suitable for pharmaceutical development, with comprehensive testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with each batch, detailing results for assay, chiral purity, related substances, residual solvents, and water content. Our quality commitment supports compliance with ICH Q7 guidelines and customer-specific pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0% (on anhydrous basis)
Chiral Purity (HPLC)	≥99.0% (R)-isomer
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	5.0% - 7.0% (Theoretical: ~5.9%)
Residual Solvents (GC)	Meets ICH Q3C limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.