Description

(2S,3S)-2-Amino-3-Ethoxybutanoic Acid Hydrochloride, 80% E.E., 99+% is a high-purity, non-natural amino acid derivative with a defined stereochemistry. This compound matters as a critical chiral building block and intermediate for the synthesis of complex pharmaceuticals and bioactive molecules, where its specific stereochemistry and high enantiomeric excess (E.E.) are essential for efficacy and regulatory approval. It is primarily needed by research institutions, pharmaceutical development labs, and fine chemical manufacturers engaged in peptide mimetics, protease inhibitor development, and other advanced medicinal chemistry applications.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other targeted therapies.
• Peptidomimetics & Constrained Peptides: Used to introduce stereochemical constraints and ethoxy side chains into peptide backbones to enhance metabolic stability and binding affinity.
• Asymmetric Synthesis: Serves as a starting material or auxiliary in asymmetric catalytic reactions and the synthesis of other non-proteinogenic amino acids.
• Biochemical Research: Employed in enzymology studies as a substrate or inhibitor analog to investigate enzyme mechanisms and specificity.
• Ligand & Catalyst Development: Utilized for constructing chiral ligands and organocatalysts used in enantioselective transformations.
• Agrochemical Research: Potential intermediate in the development of chiral active ingredients for crop protection agents.

Basic Information

Product Name	(2S,3S)-2-Amino-3-Ethoxybutanoic Acid Hydrochloride, 80% E.E., 99+%
CAS No.	205503-95-3
Molecular Formula	C6H14ClNO3
Molecular Weight	183.63 g/mol
Synonyms	(2S,3S)-2-Amino-3-ethoxybutanoic acid hydrochloride; L-threo-2-Amino-3-ethoxybutyric acid hydrochloride; 3-Ethoxy-L-threonine hydrochloride; (2S,3S)-3-Ethoxy-2-aminobutanoic acid HCl; Ethoxy-L-threonine HCl; Aminoethoxybutanoic acid hydrochloride (stereospecific); 2-Amino-3-ethoxybutyric acid HCl (L-threo form); NSC 760463 (Hydrochloride)
EINECS	Contact for details

Quality Control

Our (2S,3S)-2-Amino-3-Ethoxybutanoic Acid Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess verification and purity assessment, to ensure it meets the specified 99+% purity and 80% E.E. standards. Certificates of Analysis (COA) with full chromatographic data are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under anhydrous conditions to prevent degradation. For long-term storage, consider inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 99.0%
Enantiomeric Excess (Chiral HPLC)	≥ 80.0% E.E. (2S,3S)
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.