Description

Adenosine, 2-Chloro-2'-C-Methyl- is a chemically modified nucleoside analog of significant interest in pharmaceutical research and development. This compound serves as a critical synthetic intermediate and a key pharmacophore in the design of novel antiviral and anticancer therapeutics. It is primarily sought after by research institutions and pharmaceutical companies engaged in the synthesis of nucleotide-based drugs, particularly for targeting viral polymerases and modulating cellular signaling pathways. The high-purity material is essential for ensuring the efficacy and safety profile of downstream active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of nucleoside analog prodrugs for antiviral applications.
• Antiviral Drug Research: Used in the development of potential therapeutics targeting viruses such as hepatitis C virus (HCV) and other RNA viruses.
• Oncology Research: Investigated as a precursor for compounds that may inhibit tumor cell proliferation or induce apoptosis.
• Biochemical Tool: Employed in enzymatic studies to understand substrate specificity and inhibition mechanisms of kinases and polymerases.
• Medicinal Chemistry: Serves as a core scaffold for structure-activity relationship (SAR) studies to optimize potency and selectivity.
• Reference Standard: Used as a high-purity analytical standard for quality control and method validation in API manufacturing.

Basic Information

Product Name	Adenosine, 2-Chloro-2'-C-Methyl-
CAS No.	205171-11-5
Molecular Formula	C11H14ClN5O4
Molecular Weight	315.71 g/mol
Synonyms	2-Chloro-2'-C-methyladenosine; 2'-C-Methyl-2-chloroadenosine; 2-Chloro-2'-methyladenosine; 9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-3-methyloxolan-2-yl]-2-chloropurine; 2-Chloro-2'-C-methyl-adenosine; 2'-C-Methyl-2-chloro-adenosine; Adenosine, 2-chloro-2'-C-methyl-; 2-Cl-2'-C-Me-Ado
EINECS	Contact for details

Quality Control

Our Adenosine, 2-Chloro-2'-C-Methyl- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and tests for residual solvents and heavy metals, to ensure it meets the stringent requirements for pharmaceutical research. Certificates of Analysis (COA) detailing all specifications are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.