Description

L-Lysine-2-15N Dihydrochloride is a stable isotope-labeled derivative of the essential amino acid L-Lysine, specifically enriched with the 15N isotope at the 2-position. This compound is a critical tool for advanced research in metabolism, protein dynamics, and nutritional studies, providing a non-radioactive tracer for precise quantification and pathway analysis. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and life science research sectors who require high-purity, isotopically-labeled standards for mass spectrometry, NMR spectroscopy, and clinical diagnostics.

Application

• Metabolic Pathway Tracing: Used as a stable isotope tracer in mass spectrometry (MS) and nuclear magnetic resonance (NMR) studies to investigate amino acid metabolism, protein synthesis rates, and turnover in biological systems.
• Proteomics & Biomarker Research: Serves as an internal standard for the accurate quantification of lysine and its metabolites in complex biological samples like plasma, urine, and tissue homogenates.
• Pharmaceutical Development: Employed in the research and development of new drugs, particularly in pharmacokinetic (PK) and pharmacodynamic (PD) studies to track the incorporation of labeled amino acids into therapeutic proteins or peptides.
• Nutritional Science: Applied in human and animal nutrition studies to assess protein quality, amino acid bioavailability, and whole-body protein metabolism under different dietary conditions.
• Clinical Diagnostics: Utilized in the development of diagnostic assays for inborn errors of metabolism related to lysine catabolism, such as hyperlysinemia.
• Biochemical Reagent: Acts as a high-purity labeled building block for the chemical synthesis of isotopically-labeled peptides, proteins, and other complex biomolecules.

Basic Information

Product Name	L-Lysine-2-15N Dihydrochloride
CAS No.	204451-50-3
Molecular Formula	C6H1515N2O2 • 2HCl
Molecular Weight	231.12 g/mol (for monoisotopic 15N)
Synonyms	(2S)-2,6-Diamino-2-(15N)hexanoic acid dihydrochloride
L-Lysine-2-15N dihydrochloride
L-(+)-Lysine-2-15N dihydrochloride
2-15N-L-Lysine • 2HCl
Stable isotope-labeled L-Lysine dihydrochloride
15N-L-Lysine dihydrochloride (position-specific)
H-Lys(15N)-OH • 2HCl
EINECS	Contact for details

Quality Control

Our L-Lysine-2-15N Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR and Mass Spectrometry, to confirm isotopic enrichment, chemical purity, and identity. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data on isotopic purity, chemical purity, specific rotation, residual solvent analysis, and heavy metals. Our quality commitment ensures the material is suitable for sensitive analytical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture, which can affect stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (15N at 2-position)	≥ 98 atom % 15N
Specific Rotation	+20.0° to +22.0° (c=2 in 6N HCl)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.