Description

(4S,5R,6R)-5-Acetamido-4-Guanidino-6-((1R,2R)-2,3-Dihydroxy-1-Methoxypropyl)-5,6-Dihydro-4H-Pyran-2-Carboxylic Acid CAS NO 203120-17-6 is a complex, high-purity chiral compound that serves as a critical advanced intermediate in modern pharmaceutical synthesis. Its value lies in its sophisticated stereochemistry and functional groups, which are essential for constructing potent, targeted active pharmaceutical ingredients (APIs). This product is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development and production of novel antiviral and antibacterial therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of neuraminidase inhibitors and other complex bioactive molecules.
• Antiviral Drug Research: Used in the research and development of next-generation antiviral agents targeting influenza and other viruses.
• Medicinal Chemistry: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Process Chemistry Development: Employed in the scale-up and optimization of synthetic routes for commercial API manufacturing.
• Biochemical Research: Used as a reference standard or inhibitor in enzymatic studies related to sialic acid metabolism.
• Custom Synthesis: A starting material for the custom synthesis of labeled compounds (e.g., deuterated, C13) for pharmacokinetic and metabolic studies.

Basic Information

Product Name	(4S,5R,6R)-5-Acetamido-4-Guanidino-6-((1R,2R)-2,3-Dihydroxy-1-Methoxypropyl)-5,6-Dihydro-4H-Pyran-2-Carboxylic Acid
CAS No.	203120-17-6
Molecular Formula	C13H24N4O8
Molecular Weight	364.35 g/mol
Synonyms	5-Acetamido-4-guanidino-6-(1,2,3-trideoxy-2,3-dihydroxy-1-methoxy-D-erythro-hex-1-enopyranos-1-yl)-5,6-dihydro-4H-pyran-2-carboxylic Acid; Relenza Intermediate; Zanamivir Intermediate; (1R,2R,3S,4R,5S)-4-Guanidino-3-((1R,2R)-2,3-dihydroxy-1-methoxypropyl)-2-[(1S)-1-hydroxyethyl]-3,4-dihydro-2H-pyran-6-carboxylic Acid derivative; 4H-Pyran-2-carboxylic Acid, 5-(acetylamino)-4-guanidino-6-[(1R,2R)-2,3-dihydroxy-1-methoxypropyl]-5,6-dihydro-, (4S,5R,6R)-; GW 420867X Intermediate; Neuraminidase Inhibitor Intermediate.
EINECS	Contact for details

Quality Control

Our (4S,5R,6R)-5-Acetamido-4-Guanidino-6-((1R,2R)-2,3-Dihydroxy-1-Methoxypropyl)-5,6-Dihydro-4H-Pyran-2-Carboxylic Acid is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided and can be tailored to meet specific client or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% de
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.