Description

L-Threonine (U-13C4) is a uniformly carbon-13 labeled isotopologue of the essential amino acid L-Threonine, identified by CAS NO 202468-39-1. This high-purity stable isotope-labeled compound is critical for advanced research requiring precise metabolic and pharmacokinetic tracing. It is primarily utilized by scientists and manufacturers in the pharmaceutical, biotechnology, and life science sectors for applications such as quantitative mass spectrometry, NMR spectroscopy, and metabolic pathway analysis.

Application

• Internal Standard for Quantitative Mass Spectrometry (MS): Used as a precise internal standard in LC-MS and GC-MS analyses for accurate quantification of unlabeled L-Threonine in complex biological matrices.
• Metabolic Flux Analysis (MFA): Enables the detailed tracing and modeling of metabolic pathways in cell cultures, tissues, or whole organisms.
• NMR Spectroscopy Studies: Serves as a probe for structural and dynamic studies of proteins and biomolecules due to its distinct 13C NMR signature.
• Drug Metabolism and Pharmacokinetics (DMPK): Employed in the development and validation of assays to study the absorption, distribution, metabolism, and excretion of pharmaceutical compounds.
• Biomedical Research: Facilitates research into amino acid metabolism disorders, protein synthesis studies, and nutritional science.
• Production of Labeled Biomolecules: Acts as a building block for the biosynthesis of more complex 13C-labeled peptides, proteins, or other metabolites.

Basic Information

Product Name	L-Threonine (U-13C4)
CAS No.	202468-39-1
Molecular Formula	¹³C₄H₉NO₃
Molecular Weight	123.08 (for ¹³C₄ isotopologue)
Synonyms	(2S,3R)-2-Amino-3-hydroxy[U-¹³C₄]butanoic acid; L-2-Amino-3-hydroxy[U-¹³C₄]butyric acid; (2S,3R)-[U-¹³C₄]Threonine; L-Threonine-¹³C₄; L-Threonine (13C4); Uniformly Labeled 13C4 L-Threonine; Threonine-13C4; [U-13C4]-L-Threonine
EINECS	Contact for details

Quality Control

Our L-Threonine (U-13C4) is manufactured under controlled conditions to ensure exceptional isotopic and chemical purity. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS analysis, to verify identity, isotopic enrichment (typically >99 atom % ¹³C), and chemical purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation due to moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 99 atom % ¹³C
Optical Rotation	[α]²⁰D: -28.0° to -30.0° (c=1 in H₂O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.