Description

L-Arginine-13C6, 15N4 Hydrochloride is a stable isotope-labeled form of the essential amino acid arginine, where six carbon atoms and four nitrogen atoms are replaced with their heavy isotopes. This high-purity labeled compound is critical for advanced quantitative analysis using mass spectrometry, providing unparalleled accuracy and sensitivity in metabolic and proteomic research. It is an indispensable tool for scientists and researchers in pharmaceutical development, clinical diagnostics, and nutritional studies who require definitive internal standards for precise measurement of arginine and related metabolic pathways.

Application

• Mass Spectrometry Internal Standard: Serves as a quantitative reference standard in LC-MS/MS and GC-MS analysis for accurate measurement of endogenous L-arginine levels in biological samples.
• Metabolic Flux Analysis (MFA): Used in tracer studies to map and quantify metabolic pathways, particularly in nitric oxide synthesis, urea cycle, and polyamine biosynthesis.
• Proteomics & Biomarker Discovery: Enables precise, isotope-coded quantification of peptides and proteins in complex mixtures for disease biomarker identification.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Essential for tracking the absorption, distribution, metabolism, and excretion of arginine-based drug candidates.
• Clinical Diagnostic Assays: Used in the development and validation of high-precision diagnostic tests for conditions like cardiovascular disease, renal function, and inborn errors of metabolism.
• Nutritional Research: Facilitates the study of protein metabolism, amino acid turnover, and the metabolic effects of dietary supplements.

Basic Information

Product Name	L-Arginine-13C6, 15N4 Hydrochloride
CAS No.	202468-25-5
Molecular Formula	C613C6 H18 N415N4 • HCl
Molecular Weight	~237.66 (for unlabeled form C6H14N4O2 • HCl: 210.66) Contact for exact labeled MW
Synonyms	(2S)-2-Amino-5-(carbamimidamido)-13C6,15N4-pentanoic acid hydrochloride; L-Arginine-13C6,15N4 HCl; Arg-13C6,15N4 hydrochloride; Stable Isotope Labeled L-Arginine HCl; [U-13C6,15N4]-L-Arginine monohydrochloride; 13C6,15N4-L-Arginine•HCl; L-[13C6,15N4]Arginine hydrochloride
EINECS	Contact for details

Quality Control

Every batch of L-Arginine-13C6, 15N4 Hydrochloride is manufactured and analyzed under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Our products undergo rigorous quality testing, including advanced spectroscopic and chromatographic methods, to ensure compliance with stringent industry standards for stable isotope-labeled compounds. Certificates of Analysis (COA) are provided with each shipment, detailing isotopic enrichment (Atom % 13C and 15N), chemical purity, and analytical results.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or CoA. This material is hygroscopic (moisture-sensitive). Keep the container tightly sealed in a dry environment to prevent absorption of moisture, which may affect stability and accurate weighing.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (Atom % 13C)	≥ 99%
Isotopic Enrichment (Atom % 15N)	≥ 99%
Chemical Purity (HPLC)	≥ 98%
Optical Rotation	[α]20/D: +21.0° to +27.0° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.