Description

L-Serine-13C3, 15N is a stable isotope-labeled analog of the essential amino acid L-serine, where three carbon atoms are replaced with the 13C isotope and the nitrogen atom is replaced with 15N. This compound is a critical tool for advanced research in metabolomics, proteomics, and pharmaceutical development, enabling precise metabolic pathway tracing and quantitative analysis. It is primarily utilized by scientists and manufacturers in the fields of nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), clinical diagnostics, and drug discovery.

Application

• Metabolic Flux Analysis (MFA): As a tracer to study central carbon metabolism, glycine, and one-carbon unit metabolism in cell cultures and biological systems.
• Quantitative Proteomics & Biomarker Discovery: Used as an internal standard for the accurate quantification of serine and related metabolites via LC-MS/MS and GC-MS platforms.
• Pharmaceutical Research & Development: Employed in the synthesis of isotopically labeled drug candidates and metabolites for pharmacokinetic (PK) and absorption, distribution, metabolism, and excretion (ADME) studies.
• NMR Spectroscopy: Serves as a valuable standard for spectral calibration and assignment in complex biological mixture analysis due to its distinct isotopic signature.
• Clinical Diagnostics: Potential use in developing advanced assays for inborn errors of metabolism related to serine biosynthesis and utilization.
• Nutritional Science Research: To investigate the role of serine in cellular processes, immune function, and neurological health under controlled isotopic conditions.

Basic Information

Product Name	L-Serine-13C3, 15N
CAS No.	202407-34-9
Molecular Formula	¹³C₃H₇¹⁵NO₃
Molecular Weight	108.06 (for ¹³C₃, ¹⁵N)
Synonyms	(2S)-2-Amino-3-hydroxypropanoic-13C3,15N; L-Serine-13C3,15N; Serine-13C3,15N; (S)-Serine-13C3,15N; 13C3,15N-L-Serine; Isotopically labeled L-serine; Stable isotope-labeled serine; ¹³C₃,¹⁵N-L-Serine
EINECS	Contact for details

Quality Control

Our L-Serine-13C3, 15N is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (Atom % 13C and 15N), chemical purity, and specific analytical data. We adhere to rigorous in-process controls and final release testing to meet the exacting standards required for analytical and synthetic use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation or storage under an inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % 13C)	≥ 99%
Isotopic Enrichment (Atom % 15N)	≥ 98%
Chemical Purity (Titration)	≥ 98.0%
Optical Rotation	[α]20/D: +13.5° to +15.5° (c=1 in H2O)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.