Description

L-4-Hydroxyphenylalanine-13C9,15N is a stable isotope-labeled analog of L-tyrosine, where nine carbon atoms and the nitrogen atom are replaced with their heavy isotopes. This compound is essential for advanced analytical research, providing an internal standard for precise quantification and metabolic pathway tracing in mass spectrometry. It is primarily used by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for drug metabolism studies (DMPK), proteomics, and clinical research.

Application

• Mass Spectrometry Internal Standard: Serves as a critical quantitative reference standard in LC-MS and GC-MS analyses for accurate measurement of L-tyrosine and related metabolites.
• Drug Metabolism & Pharmacokinetics (DMPK): Used in tracer studies to elucidate the absorption, distribution, metabolism, and excretion (ADME) profiles of pharmaceutical compounds.
• Proteomics & Metabolic Research: Enables the study of protein turnover, amino acid metabolism, and biomarker discovery in complex biological systems.
• Clinical Diagnostics: Facilitates the development of highly accurate diagnostic assays for inborn errors of metabolism, such as tyrosinemia.
• Nutritional Science Research: Applied in studies investigating amino acid utilization, protein synthesis, and metabolic flux in nutritional interventions.
• Synthesis of Labeled Compounds: Acts as a building block for the synthesis of more complex isotopically labeled peptides, proteins, or pharmaceutical agents.

Basic Information

Product Name	L-4-Hydroxyphenylalanine-13C9,15N
CAS No.	202407-26-9
Molecular Formula	13C9C10H11NO4
Molecular Weight	~204.15 g/mol (for 13C9,15N labeled form)
Synonyms	L-Tyrosine-13C9,15N; (2S)-2-Amino-3-(4-hydroxyphenyl)propanoic acid-13C9,15N; L-Tyr-13C9,15N; 13C9,15N-L-Tyrosine; Isotopically labeled L-tyrosine; 4-Hydroxy-L-phenylalanine-13C9,15N; Stable isotope-labeled tyrosine; TYR-13C9,15N
EINECS	Contact for details

Quality Control

Every batch of L-4-Hydroxyphenylalanine-13C9,15N is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity, with comprehensive testing including NMR and Mass Spectrometry for isotopic enrichment verification, and HPLC for chemical purity assessment. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming specifications for identity, purity (HPLC), isotopic purity, and residual solvents.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99 atom % 13C; ≥ 99 atom % 15N
Chemical Purity (HPLC)	≥ 98.0%
Optical Rotation	[α]20/D: Specific range provided on COA
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.