Description

L-Tryptophan-13C11,15N2 is a stable isotope-labeled analog of the essential amino acid L-Tryptophan, where 11 carbon atoms and 2 nitrogen atoms are replaced with their heavy isotopes. This compound is a critical tool for advanced quantitative mass spectrometry, enabling precise metabolic flux analysis, protein turnover studies, and pharmacokinetic research. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and CROs (Contract Research Organizations) engaged in tracer studies and biomarker discovery.

Application

• Stable Isotope Tracer Studies: Used in metabolic pathway analysis (e.g., serotonin, melatonin, kynurenine pathways) to track and quantify biochemical fluxes in cell cultures, tissues, or whole organisms.
• Quantitative Proteomics & Metabolomics: Serves as an internal standard in LC-MS/MS and GC-MS workflows for the absolute quantification of tryptophan and its metabolites in complex biological samples.
• Drug Metabolism and Pharmacokinetics (DMPK): Employed in the development and validation of bioanalytical methods for novel therapeutics, ensuring accurate measurement of drug and endogenous compound levels.
• Nutritional Research: Used in studies investigating protein synthesis, amino acid requirements, and the metabolic fate of dietary tryptophan.
• Biomedical Research: Facilitates research into neurological disorders, immune function, and sleep regulation by providing a precise tool to study tryptophan-related biochemistry.

Basic Information

Product Name	L-Tryptophan-13C11,15N2
CAS No.	202406-50-6
Molecular Formula	¹³C₁₁H₁₂N¹⁵N¹O₂
Molecular Weight	~213.19 g/mol (labeled)
Synonyms	(2S)-2-Amino-3-(1H-indol-3-yl)propanoic-13C11,15N2 acid; Tryptophan-13C11,15N2; L-TRP-13C11,15N2; Tryptophan (U-13C11, 15N2); (S)-Tryptophan-13C11,15N2; 1H-Indole-3-alanine-13C11,15N2; Isotopically labeled L-Tryptophan; Tracer L-Tryptophan
EINECS	Contact for details

Quality Control

Our L-Tryptophan-13C11,15N2 is manufactured under strict quality controls to ensure high chemical and isotopic purity, which is essential for reliable scientific data. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % 13C and 15N), chemical purity (by HPLC), chiral purity, and residual solvent content. We adhere to cGMP principles for research chemicals, and specifications can be tailored to meet the stringent requirements of method development and validation in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture, which can affect stability and accurate weighing.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C; ≥ 99 atom % 15N
Chiral Purity ([α]D)	≥ 99.0% L-isomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.