Description

Dl-Lysine-1-13C Dihydrochloride is a stable isotope-labeled derivative of the essential amino acid lysine, where the carbon-13 atom is specifically incorporated at the 1-position. This compound is a critical tool for advanced research in metabolism, proteomics, and pharmacokinetics, enabling precise tracking and quantification of biochemical pathways. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and diagnostic manufacturers for applications requiring high isotopic purity and chemical stability.

Application

• Metabolic Pathway Tracing: Used as a stable isotope tracer in mass spectrometry (MS) and nuclear magnetic resonance (NMR) studies to investigate amino acid metabolism, protein turnover, and nutrient utilization in biological systems.
• Quantitative Proteomics & Biomarker Discovery: Serves as an internal standard for the absolute quantification of proteins and peptides in SILAC (Stable Isotope Labeling by Amino acids in Cell culture) and other mass spectrometry-based proteomic workflows.
• Drug Metabolism and Pharmacokinetics (DMPK): Employed in the development and validation of bioanalytical methods for tracking labeled drug compounds and their metabolites in preclinical and clinical studies.
• Nutritional Research: Facilitates studies on protein synthesis, amino acid requirements, and the metabolic fate of dietary components in humans and animals.
• Diagnostic Reagent Manufacturing: Used in the production of calibrators and controls for in-vitro diagnostic (IVD) assays that measure amino acid levels, such as in newborn screening for metabolic disorders.
• Chemical Reference Standard: Acts as a certified reference material (CRM) for quality control and method validation in analytical laboratories.

Basic Information

Product Name	Dl-Lysine-1-13C Dihydrochloride
CAS No.	202326-50-9
Molecular Formula	C613CH15Cl2N2O2
Molecular Weight	221.13 g/mol (for 13C1 isotopologue)
Synonyms	DL-Lysine-1-13C dihydrochloride; (RS)-2,6-Diaminohexanoic-1-13C acid dihydrochloride; Lysine-1-13C HCl; (±)-Lysine-1-13C dihydrochloride; H-DL-Lys-1-13C-OH·2HCl; 2,6-Diaminocaproic-1-13C acid dihydrochloride; [1-13C]-DL-Lysine·2HCl; Labeled Lysine dihydrochloride
EINECS	Contact for details

Quality Control

Our Dl-Lysine-1-13C Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high chemical and isotopic purity, identity confirmation, and the absence of specific impurities. Certificates of Analysis (COA) are provided, detailing results for assay (by HPLC or titration), isotopic enrichment (by MS or NMR), chiral purity, residual solvents, and heavy metals. We support compliance with relevant research and quality standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to 13C labeling pattern
Assay (HPLC)	≥98.0% (on anhydrous basis)
Isotopic Enrichment	≥99 atom % 13C
Optical Purity (Chiral HPLC)	DL-mixture (Racemic)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.