Description

D-[Ul-13C5]Ribose is a stable isotope-labeled analog of the essential pentose sugar D-ribose, where all five carbon atoms are uniformly enriched with the carbon-13 isotope. This high-purity labeled compound is critical for advanced metabolic research, enabling precise tracking and quantification of ribose utilization and nucleotide biosynthesis pathways. It is an indispensable tool for researchers and manufacturers in pharmaceutical development, metabolic flux analysis (MFA), and nuclear magnetic resonance (NMR) spectroscopy.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to map and quantify the pentose phosphate pathway and nucleotide synthesis in cell cultures and biological systems.
• NMR Spectroscopy: Serves as a crucial internal standard or labeled substrate for structural and dynamic studies of biomolecules.
• Pharmaceutical R&D: Employed in the development and testing of novel antiviral and anticancer agents that target nucleotide metabolism.
• Biochemical Research: Facilitates studies on RNA synthesis, glycosylation processes, and cellular energy metabolism.
• Isotope-Labeled Standard Production: Acts as a precursor for the synthesis of more complex carbon-13 labeled nucleotides and nucleosides.
• Nutritional Science Research: Used in studies investigating the metabolic fate and efficacy of ribose supplements.

Basic Information

Product Name	D-[Ul-13C5]Ribose
CAS No.	202114-47-4
Molecular Formula	¹³C₅H₁₀O₅
Molecular Weight	155.09 g/mol (for ¹³C₅ isotopologue)
Synonyms	D-Ribose (U-13C5); D-Ribose-13C5; (2R,3R,4R)-2,3,4,5-Tetrahydroxypentanal-13C5; Uniformly Labeled 13C5 D-Ribose; [U-13C5]-D-Ribose; 13C5 Ribose; Isotopically Labeled D-Ribose; Pentose-13C5 sugar
EINECS	Contact for details

Quality Control

Our D-[Ul-13C5]Ribose is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity, suitable for sensitive analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically >99 atom % 13C), chemical purity (by HPLC), and specific analytical data. We adhere to cGMP principles for consistent production and supply reliability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Water Content (KF)	≤ 1.0%
Specific Optical Rotation	-20.0° to -23.0° (c=1 in H2O)
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.