Description

Anandamide [Arachidonyl-5,6,8,9,11,12,14,15-3H] is a high-specific-activity, tritium-labeled analog of the endogenous cannabinoid neurotransmitter anandamide, with the CAS registry number 202062-33-7. This radiochemical is an essential tool for high-sensitivity research, enabling precise tracking and quantification of anandamide binding, uptake, and metabolism in biological systems. It is critically needed by pharmaceutical R&D teams, academic neuroscientists, and clinical researchers focused on the endocannabinoid system, pain pathways, and neurological disorders.

Application

• Receptor Binding Assays: Quantitative analysis of cannabinoid receptor (CB1/CB2) affinity and saturation binding studies.
• Metabolic Pathway Tracing: Investigation of anandamide biosynthesis, degradation by fatty acid amide hydrolase (FAAH), and reuptake mechanisms.
• Autoradiography & Imaging: Used in tissue section mapping to localize endocannabinoid system components in the brain and peripheral nervous system.
• Drug Discovery Screening: A key tracer in high-throughput screens for novel FAAH inhibitors or endocannabinoid transport modulators.
• Pharmacokinetic Studies: Tracing the distribution, tissue uptake, and clearance of anandamide and related analogs in preclinical models.
• Biochemical Mechanism Research: Studying signal transduction, enzyme kinetics, and protein-lipid interactions involving endogenous cannabinoids.

Basic Information

Item	Detail
Product Name	Anandamide [Arachidonyl-5,6,8,9,11,12,14,15-3H]
CAS No.	202062-33-7
Molecular Formula	C22H37NO2 (3H-labeled)
Molecular Weight	~ 347.5 g/mol (varies with specific activity)
Synonyms	Arachidonoylethanolamide-d4 (Tritiated); N-Arachidonoylethanolamine-[3H]; AEA-[3H]; (5Z,8Z,11Z,14Z)-N-(2-Hydroxyethyl)icosa-5,8,11,14-tetraenamide-[3H]; Endogenous Cannabinoid Ligand-[3H]; [3H]-Anandamide; Anandamide tracer; Tritium-labeled Anandamide
EINECS	Contact for details

Quality Control

Every batch of Anandamide [Arachidonyl-5,6,8,9,11,12,14,15-3H] is manufactured and analyzed under strict quality systems to ensure radiochemical purity, specific activity, and chemical stability suitable for sensitive research applications. Comprehensive analytical documentation, including Certificates of Analysis (COA) with detailed HPLC and radiometric purity data, is provided. Our quality commitment aligns with the standards required for preclinical and molecular pharmacology research.

Storage

Preserve in the original manufacturer's container as a solution in a suitable solvent (e.g., ethanol or toluene) at a recommended temperature of -20°C or below. This product is strictly light-sensitive (protect from all light exposure) and should be handled in a controlled environment appropriate for strong acid/organic solvent. For long-term stability, store under inert atmosphere and avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Identification (HPLC)	Conforms to reference standard
Specific Activity	60-120 Ci/mmol (Contact for exact value)
Radiochemical Purity (HPLC)	≥ 97%
Chemical Purity (HPLC)	≥ 95%
Concentration	1.0 mCi/mL (Nominal)
Solvent	Ethanol or Toluene/Ethanol mixture

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.