Description

Uridine (Ribose-1-13C) is a stable isotope-labeled nucleoside where the carbon-13 atom is specifically incorporated at the C-1 position of the ribose sugar moiety. This precise labeling is critical for advanced research requiring metabolic pathway tracing and quantification using techniques like Mass Spectrometry (MS) and Nuclear Magnetic Resonance (NMR) spectroscopy. It is an essential tool for scientists in pharmaceutical development, metabolomics, and biochemical research who require high-fidelity isotopic tracers to study nucleotide metabolism, RNA synthesis, and cellular energetics.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to quantify the flow of metabolites through biochemical pathways, particularly nucleotide synthesis and the pentose phosphate pathway.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as an internal standard in LC-MS/MS for the accurate quantification of uridine and its metabolites in biological matrices, enhancing assay precision.
• NMR Spectroscopy Studies: Enables detailed structural and dynamic studies of RNA and ribonucleoprotein complexes by providing a site-specific NMR probe.
• Biochemical Research: Investigates the role of uridine in cellular processes such as pyrimidine salvage pathways, glycogen synthesis, and membrane phospholipid production.
• Diagnostic Assay Development: Employed in the development of clinical assays for inborn errors of metabolism related to nucleotide and nucleoside imbalances.

Basic Information

Product Name	Uridine (Ribose-1-13C)
CAS No.	201996-62-5
Molecular Formula	C9H1213CN2O6
Molecular Weight	267.20 g/mol (for 13C1 isotopologue)
Synonyms	1-(β-D-Ribofuranosyl)uracil-1'-13C; Uridine-1'-13C; [1'-13C]Uridine; 1'-13C-Uridine; Uridine (1'-13C); Isotope-labeled Uridine; [Ribose-1-13C]Uridine; Stable Isotope Labeled Uridine
EINECS	Contact for details

Quality Control

Every batch of Uridine (Ribose-1-13C) is manufactured and analyzed under strict quality systems. We guarantee high chemical purity and isotopic enrichment, with each lot supported by a comprehensive Certificate of Analysis (COA). The COA includes data for isotopic purity (Atom % 13C), chemical purity by HPLC, and confirmation of structure by NMR and MS. Our quality commitment ensures the reliability and reproducibility required for sensitive research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under inert atmosphere to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (Atom % 13C)	≥ 99%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.