Description

L-Arginine:Hcl (13C6, 99%) is a stable isotope-labeled derivative of the essential amino acid L-Arginine, where six carbon atoms are replaced with the 13C isotope. This high isotopic purity (99%) is critical for ensuring accuracy and reliability in quantitative mass spectrometry, eliminating signal interference from unlabeled compounds. It is an indispensable tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and clinical diagnostics sectors who require precise metabolic pathway tracing, protein turnover studies, and the development of validated bioanalytical methods.

Application

• Quantitative Proteomics & Metabolomics: Used as an internal standard for the absolute quantification of L-Arginine and related metabolites in complex biological samples via LC-MS/MS.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for tracing the absorption, distribution, metabolism, and excretion (ADME) of drug candidates containing arginine moieties.
• Clinical Research & Diagnostics: Enables precise measurement of arginine levels in plasma or tissue for research into cardiovascular health, immune function, and urea cycle disorders.
• Nutritional Science: Serves as a tracer in studies investigating protein synthesis, nitric oxide production, and amino acid metabolism in vivo.
• Biopharmaceutical Manufacturing: Applied in cell culture media analysis to monitor nutrient consumption and optimize bioprocess yields for therapeutic protein production.
• Method Development & Validation: Provides a certified reference material for developing, calibrating, and validating robust analytical methods in compliance with GLP/GMP guidelines.

Basic Information

Product Name	L-Arginine:Hcl (13C6, 99%)
CAS No.	201740-91-2
Molecular Formula	C613C6H15ClN4O2 • HCl
Molecular Weight	~227.1 g/mol (labeled)
Synonyms	(2S)-2-Amino-5-(carbamimidamido)-13C6pentanoic acid hydrochloride; L-Arginine-13C6 hydrochloride; Arg-13C6 HCl; (S)-2-Amino-5-guanidino-13C6valeric acid hydrochloride; Isotope-labeled L-Arginine HCl; Stable isotope-labeled arginine HCl; L-[U-13C6]Arginine hydrochloride
EINECS	Contact for details

Quality Control

Our L-Arginine:Hcl (13C6, 99%) is manufactured under strict quality systems to ensure batch-to-batch consistency and traceability. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing critical parameters including isotopic purity (by NMR or MS), chemical purity (by HPLC), and optical rotation. We adhere to relevant industry standards for high-purity reference materials, supporting research that requires uncompromising data integrity.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Purity (13C6)	≥ 99%
Chemical Purity (HPLC)	≥ 98.0%
Optical Rotation	+21.0° to +23.0° (c=8 in 6N HCl)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.