Description

L-Arginine Hcl (1,2-13C2) is a stable isotope-labeled derivative of the essential amino acid L-Arginine, specifically enriched with carbon-13 at the 1 and 2 positions of the molecule. This high-purity labeled compound is critical for advanced research requiring precise metabolic and pharmacokinetic tracing. It is an indispensable tool for scientists in pharmaceutical development, clinical diagnostics, and nutritional research who require accurate, reliable isotopic standards for mass spectrometry and NMR studies.

Application

• Biomedical Research Tracer: Used as an internal standard in quantitative mass spectrometry (LC-MS/MS, GC-MS) for accurate measurement of L-Arginine and its metabolites in biological samples.
• Metabolic Pathway Analysis: Enables detailed tracing of arginine metabolism, nitric oxide synthesis, and urea cycle activity in cell cultures, animal models, and human clinical studies.
• Pharmaceutical Development: Supports Absorption, Distribution, Metabolism, and Excretion (ADME) studies and bioequivalence testing for drug candidates targeting cardiovascular, immune, and metabolic systems.
• Nutritional Science: Investigates protein metabolism, amino acid turnover, and the impact of dietary supplements on human physiology.
• Diagnostic Assay Development: Serves as a critical component in the calibration and validation of high-sensitivity clinical diagnostic kits.
• Stable Isotope Labeling in Cell Culture (SILAC): Facilitates quantitative proteomics research by enabling precise protein and peptide quantification.

Basic Information

Product Name	L-Arginine Hcl (1,2-13C2)
CAS No.	201740-75-2
Molecular Formula	C413C2H15ClN4O2
Molecular Weight	~ 217.63 g/mol
Synonyms	(1,2-13C2)-L-Arginine hydrochloride; L-[1,2-13C2]Arginine HCl; 13C2-L-Arginine hydrochloride; (S)-2-Amino-5-[(aminoiminomethyl)amino]-1,2-13C2-pentanoic acid hydrochloride; Labeled L-Arginine HCl; Arginine-13C2 hydrochloride; Stable Isotope-Labeled Arginine HCl; Isotopic Internal Standard for Arginine
EINECS	Contact for details

Quality Control

Every batch of our L-Arginine Hcl (1,2-13C2) is manufactured and analyzed under strict quality systems to ensure the highest isotopic and chemical purity for research applications. We provide comprehensive Certificates of Analysis (COA) detailing isotopic enrichment (typically >99 atom % 13C), chemical purity (by HPLC), and specific analytical data. Our quality commitment aligns with the rigorous standards required for analytical reference materials and pharmaceutical research.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). For long-term stability, consider storage under inert atmosphere or in a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure and labeling pattern
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Chemical Purity (Titration)	≥ 98.0%
Optical Rotation	[α]20/D: +21.0° to +23.0° (c=8 in 6N HCl)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.