Description

Glycopyrrolate Erythro Isomer is a specific stereoisomer of the anticholinergic agent glycopyrrolate, distinguished by its precise erythro configuration. This high-purity isomer is critical for advanced pharmaceutical research and development, particularly in the study of structure-activity relationships and the development of targeted therapeutic agents. It is primarily required by pharmaceutical R&D laboratories, analytical reference standard providers, and manufacturers of active pharmaceutical ingredients (APIs) for the development of antispasmodic, antiulcer, and antisialagogue medications.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for analytical method development, validation, and quality control testing of glycopyrrolate-based drug products.
• Active Pharmaceutical Ingredient (API) Intermediate: Used in the synthesis and purification of glycopyrrolate API, ensuring the final product meets stringent pharmacopeial specifications for stereochemical purity.
• Pharmacological Research: Employed in preclinical studies to investigate the specific biological activity, metabolic pathways, and receptor binding profiles attributable to the erythro isomer.
• Process Chemistry & Development: Acts as a key intermediate or starting material in optimizing synthetic routes for more efficient and stereoselective production of glycopyrrolate.
• Impurity Profiling: Utilized as a marker to identify, quantify, and control stereoisomeric impurities in bulk glycopyrrolate and finished dosage forms.

Basic Information

Product Name	Glycopyrrolate Erythro Isomer
CAS No.	201667-20-1
Molecular Formula	C19H28BrNO3
Molecular Weight	398.34 g/mol
Synonyms	3-[(Cyclopentylhydroxyphenylacetyl)oxy]-1,1-dimethylpyrrolidinium bromide (erythro isomer); Glycopyrronium bromide erythro isomer; (2RS,3SR)-3-Hydroxy-2-phenyl-N,N,N-trimethyl-2-cyclopentyl-2-hydroxyacetamide methobromide; Robinul isomer; AHR-504; Seebri isomer; Glycopyrrolate Stereoisomer
EINECS	Contact for details

Quality Control

Our Glycopyrrolate Erythro Isomer is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral HPLC for stereochemical purity, NMR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) detailing purity, identity, and impurity profiles to support regulatory filings (e.g., FDA, EMA). Specifications are designed to meet or exceed the requirements for pharmaceutical reference standards and advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Chiral Purity (Chiral HPLC)	≥99.0% (Erythro isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤1.5%; Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.