Description

L-Leucine-2-13C is a stable isotope-labeled analog of the essential amino acid L-Leucine, specifically enriched with carbon-13 at the 2-position. This precise labeling is critical for advanced research applications requiring high specificity and minimal background interference. It is an indispensable tool for scientists in pharmaceutical development, metabolic research, and nutritional studies who require reliable, high-purity isotopic tracers for mass spectrometry and NMR analysis.

Application

• Biomedical Research Tracer: Used as a stable isotopic tracer in metabolic flux analysis (MFA) and pharmacokinetic studies to track amino acid metabolism in vivo and in vitro.
• Proteomics & Mass Spectrometry: Serves as an internal standard for the accurate quantification of proteins and peptides via Liquid Chromatography-Mass Spectrometry (LC-MS/MS).
• NMR Spectroscopy: Provides a non-radioactive, site-specific label for structural elucidation and dynamic studies of biomolecules using Nuclear Magnetic Resonance.
• Drug Discovery & Development: Employed in the research and development of new therapeutic agents, particularly in studying drug-protein interactions and metabolic pathways.
• Nutritional Science: Used in clinical research to investigate protein synthesis, turnover, and the metabolic fate of branched-chain amino acids in human and animal models.
• Isotope-Labeled Standard Production: Acts as a key building block for the synthesis of more complex isotope-labeled compounds, peptides, and active pharmaceutical ingredients (APIs).

Basic Information

Item	Detail
Product Name	L-Leucine-2-13C
CAS No.	201612-66-0
Molecular Formula	C513CH13NO2
Molecular Weight	132.16 g/mol (for 13C1 labeled)
Synonyms	(2S)-2-Amino-4-methylpentanoic-2-13C acid; L-Leucine-2-13C; (S)-2-Amino-4-methylpentanoic-2-13C acid; Leucine-2-13C; (S)-Leucine-2-13C; 13C Labeled L-Leucine; [2-13C]-L-Leucine; L-Leucine (2-13C)
EINECS	Contact for details

Quality Control

Our L-Leucine-2-13C is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (Atom % 13C), chemical purity, and specific analytical data from techniques such as NMR, HPLC, and MS. We ensure compliance with relevant standards for research-grade biochemicals, and custom specifications for GMP-grade material are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent absorption of atmospheric moisture, which can affect stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C
Optical Rotation	[α]D20: +14.5° to +16.5° (c=2 in 6N HCl)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.