Description

L-Serine-13C3 is a stable isotope-labeled analog of the essential amino acid L-Serine, where all three carbon atoms are the carbon-13 (13C) isotope. This high-purity labeled compound is critical for applications requiring precise metabolic tracing and quantification in complex biological systems. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and analytical chemistry sectors for advanced mass spectrometry, nuclear magnetic resonance (NMR) spectroscopy, and clinical diagnostics.

Application

• Internal Standard for Quantitative Mass Spectrometry (MS): Essential for accurate quantification of endogenous L-Serine in bioanalytical methods like LC-MS/MS for pharmacokinetic and metabolomic studies.
• Metabolic Pathway Tracing: Used in 13C flux analysis to map and understand central carbon metabolism, glycine/serine metabolism, and one-carbon unit pathways in cell cultures, tissues, and whole organisms.
• NMR Spectroscopy Studies: Serves as a valuable probe for structural and dynamic studies of proteins, enzymes, and metabolic processes due to its distinct 13C NMR signature.
• Pharmaceutical R&D: Employed in the development and validation of assays for drug discovery, biomarker research, and investigating diseases related to serine metabolism.
• Clinical Diagnostics: Used in the calibration of advanced diagnostic equipment for the precise measurement of amino acid levels in physiological fluids.
• Production of Labeled Biomolecules: Acts as a biosynthetic precursor for the production of other 13C-labeled peptides, proteins, or complex natural products.

Basic Information

Product Name	L-Serine-13C3
CAS No.	201595-68-8
Molecular Formula	13C3H7NO3
Molecular Weight	108.05 g/mol (for 13C3)
Synonyms	(2S)-2-Amino-3-hydroxy(13C3)propanoic acid; L-13C3-Serine; (S)-2-Amino-3-hydroxy(13C3)propionic acid; Serine-13C3; (S)-Serine-13C3; L-Serine (U-13C3); L-Serine (13C3, 99%)
EINECS	Contact for details

Quality Control

Our L-Serine-13C3 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity required for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (typically ≥99 atom % 13C), chemical purity (by HPLC), chiral purity, and other critical parameters. We support compliance with relevant GMP guidelines for research materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation and storage under inert atmosphere to maintain stability and isotopic integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Isotopic Enrichment	≥99 atom % 13C
Chemical Purity (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (L-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.