Description

L-Tyrosine-Ring-13C6 is a stable isotope-labeled analog of the essential amino acid L-Tyrosine, where the entire aromatic ring is uniformly labeled with carbon-13. This product is critical for advanced quantitative analysis in life science research, providing an internal standard for precise mass spectrometry measurements. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and CROs specializing in metabolic pathway analysis, protein turnover studies, and clinical biomarker discovery.

Application

• Mass Spectrometry Internal Standard: Serves as a critical quantitative reference standard in LC-MS and GC-MS analyses for accurate measurement of endogenous L-Tyrosine levels in complex biological matrices.
• Metabolic Flux Analysis (MFA): Used as a tracer to study central carbon metabolism, tyrosine biosynthesis, and related pathways in cell cultures, tissues, and whole organisms.
• Proteomics & Protein Dynamics Research: Enables the study of protein synthesis and degradation rates through Stable Isotope Labeling by Amino acids in Cell culture (SILAC) and related techniques.
• Clinical & Diagnostic Research: Facilitates the development and validation of high-precision assays for metabolic disorders related to tyrosine metabolism, such as tyrosinemia.
• Pharmaceutical Drug Metabolism & Pharmacokinetics (DMPK): Employed in ADME studies to track the metabolic fate of drug candidates and their interaction with amino acid pathways.
• Nutritional Science: Used in research to investigate amino acid absorption, utilization, and requirements in various nutritional states.

Basic Information

Product Name	L-Tyrosine-Ring-13C6
CAS No.	201595-63-3
Molecular Formula	C913C6H11NO3
Molecular Weight	197.15 g/mol (for 13C6 labeled ring)
Synonyms	(2S)-2-Amino-3-(4-hydroxyphenyl)propanoic-13C6 acid (ring); L-Tyrosine (ring-13C6); (S)-Tyrosine-ring-13C6; L-Tyrosine (phenyl-13C6); 4-Hydroxy-L-phenylalanine-ring-13C6; L-4-Hydroxyphenylalanine-ring-13C6; Tyr-ring-13C6; Stable Isotope Labeled L-Tyrosine
EINECS	Contact for details

Quality Control

Our L-Tyrosine-Ring-13C6 is manufactured under strict quality systems to ensure the highest isotopic and chemical purity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (Atom % 13C), chemical purity, and chiral purity. We adhere to relevant industry standards for stable isotope-labeled compounds, and our quality protocols are designed to support GLP and GMP-compliant research. Certificates of Analysis are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0% (chemical purity)
Isotopic Enrichment (MS)	≥ 99 atom % 13C (on labeled ring)
Chiral Purity (HPLC)	≥ 99.0% L-isomer
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.