Description

[U-Ring-13C6]-4-Hydroxybenzaldehyde is a stable isotope-labeled analog of 4-hydroxybenzaldehyde, where the aromatic ring is uniformly labeled with six carbon-13 atoms. This compound is critical for ensuring accuracy and reliability in quantitative mass spectrometry-based analyses by serving as an internal standard. It is primarily needed by analytical laboratories, pharmaceutical R&D departments, and CROs (Contract Research Organizations) engaged in metabolomics, pharmacokinetic studies, and environmental fate analysis where precise quantification of the parent compound is required.

Application

• Internal Standard for LC-MS/MS: Used as a high-purity isotopic internal standard for the accurate quantification of 4-hydroxybenzaldehyde and related metabolites in complex biological matrices like plasma, urine, and tissue homogenates.
• Pharmaceutical Metabolism Studies: Essential in drug metabolism and pharmacokinetics (DMPK) research to track the absorption, distribution, metabolism, and excretion (ADME) of compounds derived from or containing the 4-hydroxybenzaldehyde moiety.
• Biomarker Research: Employed in metabolomic and proteomic studies to identify and quantify potential biomarkers of disease or exposure in clinical and preclinical samples.
• Environmental Analysis: Facilitates the precise measurement of phenolic aldehydes in environmental samples, aiding in pollution monitoring and degradation studies.
• Food and Flavor Chemistry: Supports analytical methods for the quantification of natural or synthetic flavor compounds and their degradation products in food products.
• Method Development and Validation: Serves as a key reagent for developing, optimizing, and validating sensitive and specific analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).

Basic Information

Item	Details
Product Name	[U-Ring-13C6]-4-Hydroxybenzaldehyde
CAS No.	201595-48-4
Molecular Formula	C7H6O2 (with U-13C6 ring)
Molecular Weight	~128.04 (for 13C6 labeled form)
Synonyms	4-Hydroxybenzaldehyde-13C6 (ring); p-Hydroxybenzaldehyde-13C6; 4-Formylphenol-13C6; [U-13C6]-4-Hydroxybenzaldehyde; 4-Hydroxybenzaldehyde (ring-13C6); p-Hydroxybenzaldehyde (aromatic ring-13C6); Isotopically Labeled 4-Hydroxybenzaldehyde; 4-Hydroxybenzaldehyde-13C6 (U)
EINECS	Contact for details

Quality Control

Every batch of [U-Ring-13C6]-4-Hydroxybenzaldehyde is manufactured and tested under strict quality systems. We guarantee high chemical and isotopic purity, with rigorous analytical controls including NMR, HPLC, and mass spectrometry to confirm identity, purity, and isotopic enrichment. Certificates of Analysis (COA) are provided with each shipment, detailing batch-specific results for all critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. The material is light-sensitive and easily oxidized; prolonged exposure to air, light, or elevated temperatures should be avoided to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 99 atom % 13C (on labeled positions)
Chemical Purity	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.