Description

L-Dopa (Ring-13C6, 99%) is a stable isotope-labeled analog of the critical neurotransmitter precursor L-3,4-dihydroxyphenylalanine, where six carbon atoms in the aromatic ring are enriched with the 13C isotope. This high isotopic purity (99%) is essential for ensuring accuracy and reliability in advanced analytical and metabolic research. It is primarily required by pharmaceutical R&D laboratories, clinical research organizations, and academic institutions engaged in quantitative mass spectrometry, pharmacokinetic studies, and metabolic pathway tracing.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in liquid chromatography-tandem mass spectrometry for the precise measurement of endogenous L-Dopa and its metabolites in biological matrices.
• Metabolic Flux Analysis (MFA): Used as a tracer to study the dynamics of dopamine synthesis, turnover, and related pathways in neurological research and drug development.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug absorption, distribution, metabolism, and excretion in preclinical and clinical trials for Parkinson's disease therapies.
• Biochemical Research: Facilitates the investigation of enzyme kinetics, particularly of aromatic L-amino acid decarboxylase (AADC), and other dopaminergic system mechanisms.
• Diagnostic Assay Development: Employed in the development and calibration of high-sensitivity diagnostic tests for neurotransmitter disorders.

Basic Information

Product Name	L-Dopa (Ring-13C6, 99%)
CAS No.	201417-12-1
Molecular Formula	C913C6H11NO4
Molecular Weight	203.15 (for 13C6 labeled form)
Synonyms	Levodopa-13C6; (2S)-2-Amino-3-(3,4-dihydroxyphenyl-13C6)propanoic acid; L-3,4-Dihydroxyphenylalanine-13C6; L-(-)-Dopa-13C6; 13C6-L-DOPA; Isotopically Labeled L-DOPA; Carbon-13 Labeled Levodopa
EINECS	Contact for details

Quality Control

Every batch of L-Dopa (Ring-13C6, 99%) is manufactured and analyzed under strict quality protocols to ensure exceptional isotopic and chemical purity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, providing detailed results for isotopic enrichment, chemical purity, and identity confirmation via advanced spectroscopic methods.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (13C)	≥ 99%
Chemical Purity (HPLC)	≥ 98.0%
Optical Rotation	Specific range provided on COA
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.