Description

Tenofovir Disoproxil is a prodrug of tenofovir, a potent nucleotide reverse transcriptase inhibitor (NRTI). This compound is a critical active pharmaceutical ingredient (API) essential for the formulation of antiviral medications. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development and production of treatments for viral infections.

Application

• Antiviral Drug Manufacturing: Primary active pharmaceutical ingredient (API) in the production of antiviral tablets and capsules.
• HIV Treatment: Key component in fixed-dose combination therapies for the management of Human Immunodeficiency Virus (HIV-1) infection.
• Hepatitis B Treatment: Used in formulations for the treatment of chronic hepatitis B virus (HBV) infection.
• Pharmaceutical Research: Serves as a reference standard and building block in antiviral drug discovery and development programs.
• Pre-Exposure Prophylaxis (PrEP): API for medications used in HIV prevention strategies.
• Generic Drug Production: Essential for manufacturers producing bioequivalent generic versions of branded antiviral drugs.

Basic Information

Product Name	Tenofovir Disoproxil
CAS No.	201341-05-1
Molecular Formula	C19H30N5O10P
Molecular Weight	519.45 g/mol
Synonyms	Tenofovir Disoproxil Fumarate (common salt form); TDF; Bis(POC)PMPA; 9-[(R)-2-[[Bis[[(isopropoxycarbonyl)oxy]methoxy]phosphinyl]methoxy]propyl]adenine; PMPA Disoproxil; GS 4331; Viread (brand name reference); Gilead 4331
EINECS	Contact for details

Quality Control

Our Tenofovir Disoproxil is manufactured under strict quality management systems. The product undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications, including identity, assay, and impurity profile verification. Certificates of Analysis (COA) confirming compliance with relevant specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.