Description

D-[1-13C,1-2H]Glucose is a stable isotope-labeled analog of D-glucose, specifically enriched with carbon-13 at the C-1 position and deuterium at the same carbon. This compound is an essential tool for advanced metabolic research, providing a non-radioactive tracer for precise tracking of glucose utilization and metabolic flux in biological systems. It is primarily used by researchers and scientists in pharmaceutical development, clinical diagnostics, and academic biochemistry who require high-fidelity isotopic labeling for mass spectrometry (MS) and nuclear magnetic resonance (NMR) studies.

Application

• Metabolic Flux Analysis (MFA): Used as a stable isotopic tracer to quantify intracellular metabolic pathway rates in cell cultures, tissues, and whole organisms.
• Drug Metabolism & Pharmacokinetics (DMPK): Serves as an internal standard in LC-MS/MS and GC-MS assays for the accurate quantification of glucose and its metabolites in biological matrices.
• Clinical Research: Enables detailed studies of glucose metabolism disorders, such as diabetes and cancer metabolism, in human and animal models.
• Biochemical Pathway Elucidation: Facilitates the tracing of carbon and hydrogen atoms through glycolysis, the pentose phosphate pathway, and gluconeogenesis.
• NMR Spectroscopy: Provides a probe for structural and dynamic studies of enzymatic mechanisms involving glucose.
• Manufacturing of Labeled Compounds: Acts as a high-purity starting material for the synthesis of more complex isotope-labeled pharmaceuticals or biochemicals.

Basic Information

Item	Detail
Product Name	D-[1-13C,1-2H]Glucose
CAS No.	201136-45-0
Molecular Formula	C6H112H13CO6
Molecular Weight	183.15 g/mol (for 13C1, 2H1 labeled form)
Synonyms	1-13C,1-2H-D-Glucose; D-Glucose-1-13C,1-d; [1-13C,1-2H]Glucose; Isotopically Labeled D-Glucose; 13C and Deuterium Labeled Glucose; Stable Isotope-Labeled Glucose; D-Glucose (1-13C,1-2H); Metabolic Tracer Glucose
EINECS	Contact for details

Quality Control

Every batch of D-[1-13C,1-2H]Glucose is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, with comprehensive testing via NMR, HPLC, and MS to confirm identity, assay, isotopic enrichment, and the absence of critical impurities. A Certificate of Analysis (COA) detailing all specifications is provided with each shipment to ensure traceability and compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (13C)	≥ 99 atom %
Isotopic Enrichment (2H)	≥ 98 atom %
Water Content (KF)	≤ 1.0%
Specific Optical Rotation	+52.5° to +53.5° (c=10 in H2O)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.