Description

Dl-Phenyl-D5-Alanine-2,3,3-D3 is a stable isotope-labeled analog of the amino acid phenylalanine, specifically deuterated at multiple positions. This compound is critical for use as an internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy in analytical measurements. It is primarily required by pharmaceutical R&D laboratories, contract research organizations (CROs), and academic institutions engaged in advanced metabolic studies, proteomics, and pharmacokinetic research.

Application

• Mass Spectrometry Internal Standard: Essential for precise quantification of phenylalanine and related metabolites in complex biological matrices like plasma, urine, and tissue samples.
• Metabolomics & Biomarker Discovery: Used in stable isotope dilution assays to identify and quantify disease biomarkers with high specificity and sensitivity.
• Pharmacokinetic/Pharmacodynamic (PK/PD) Studies: Enables accurate tracking of drug metabolism and amino acid turnover rates in preclinical and clinical research.
• Proteomics Research: Facilitates protein quantification and turnover analysis using techniques like SILAC (Stable Isotope Labeling by Amino acids in Cell culture).
• Inborn Errors of Metabolism (IEM) Diagnostics: Serves as a reference standard in newborn screening and diagnostic assays for disorders such as Phenylketonuria (PKU).
• Nutritional Science: Used in studies investigating protein metabolism, amino acid absorption, and nutritional status.

Basic Information

Product Name	Dl-Phenyl-D5-Alanine-2,3,3-D3
CAS No.	29909-00-0
Molecular Formula	C9H6D8NO2
Molecular Weight	~171.23 g/mol
Synonyms	DL-Phenylalanine-d8; (RS)-2-Amino-3-phenylpropionic-2,3,3-d3,ring-d5 acid; Phenyl-d5-alanine-2,3,3-d3; Deuterated DL-Phenylalanine; Phenylalanine-d8; 2-Amino-3-(2,3,4,5,6-pentadeuteriophenyl)propionic-2,3,3-d3 acid; DL-α-Amino-β-phenyl-d5-propionic-2,3,3-d3 acid
EINECS	Contact for details

Quality Control

Our Dl-Phenyl-D5-Alanine-2,3,3-D3 is manufactured under strict quality systems to ensure the high isotopic purity and chemical integrity required for sensitive analytical applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing parameters such as isotopic enrichment (atom % D), chemical purity, and absence of interfering impurities. We adhere to relevant industry standards for stable isotope-labeled compounds.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.