Description

10,11-Dihydro-10,11-Dihydroxy Protriptyline is a key metabolite and synthetic intermediate of the tricyclic antidepressant protriptyline. This compound matters for its critical role in pharmaceutical research and development, particularly in metabolic pathway studies and the synthesis of high-purity active pharmaceutical ingredients (APIs). It is primarily needed by pharmaceutical manufacturers, analytical laboratories, and research institutions focused on neuropharmacology, drug metabolism, and the production of reference standards.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the analytical quantification of protriptyline and its metabolites in biological matrices.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a crucial synthetic building block in the multi-step synthesis of protriptyline hydrochloride and related tricyclic compounds.
• Metabolite Research: Essential for in vitro and in vivo studies investigating the pharmacokinetics, pharmacodynamics, and metabolic pathways of tricyclic antidepressants.
• Analytical Method Development: Employed in the development and validation of HPLC, LC-MS, and GC-MS methods for therapeutic drug monitoring and forensic analysis.
• Biochemical Research: Utilized in studies exploring the interaction of tricyclic antidepressant metabolites with neurotransmitter transporters and receptors.

Basic Information

Product Name	10,11-Dihydro-10,11-Dihydroxy Protriptyline
CAS No.	29785-65-7
Molecular Formula	C19H21NO2
Molecular Weight	295.38 g/mol
Synonyms	10,11-Dihydro-10,11-dihydroxyprotriptyline; Protriptyline Dihydrodiol; 5H-Dibenzo[a,d]cycloheptene-5-propanamine, 10,11-dihydro-10,11-dihydroxy-, (5Z)-; Protriptyline-10,11-dihydrodiol; 10,11-Dihydroxy-10,11-dihydroprotriptyline; (10R,11S)-10,11-Dihydro-10,11-dihydroxyprotriptyline; (10S,11R)-10,11-Dihydro-10,11-dihydroxyprotriptyline; Protriptyline metabolite
EINECS	Contact for details

Quality Control

Our 10,11-Dihydro-10,11-Dihydroxy Protriptyline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.