Description

3'-Azido-2',3'-Dideoxy-Thymidine-5'-Monophosphate, Sodium Salt is a chemically modified nucleoside monophosphate analog, a key intermediate in the synthesis of antiviral and antiretroviral compounds. Its value lies in its role as a critical building block for research and development of nucleotide-based therapeutics, particularly those targeting viral polymerases. This high-purity intermediate is essential for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions engaged in antiviral drug discovery, mechanism of action studies, and biochemical assay development.

Application

• Antiviral Drug Synthesis: A crucial phosphoramidite precursor in the solid-phase synthesis of oligonucleotide analogs for antiviral applications.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate the mechanisms of viral reverse transcriptase and DNA polymerase.
• Prodrug Development: Serves as an intermediate for the development of prodrugs designed to improve cellular uptake and pharmacokinetics of active nucleoside analogs.
• Labeled Compound Synthesis: Acts as a starting material for the synthesis of radiolabeled or fluorescently tagged probes for tracking and imaging studies.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to develop novel nucleoside derivatives with enhanced efficacy and reduced toxicity.

Basic Information

Product Name	3'-Azido-2',3'-Dideoxy-Thymidine-5'-Monophosphate, Sodium Salt
CAS No.	29706-85-2
Molecular Formula	C10H12N5NaO7P
Molecular Weight	368.19 g/mol
Synonyms	AZT Monophosphate Sodium Salt; 3'-Azido-3'-deoxythymidine 5'-monophosphate sodium salt; 3'-N3-2',3'-ddTMP Na; Thymidine, 2',3'-dideoxy-3'-azido-, 5'-(dihydrogen phosphate), sodium salt; AZT-5'-MP Sodium; 3'-Azido-ddTMP Sodium Salt; NSC 684590; 5'-Monophosphate of Zidovudine Sodium Salt
EINECS	Contact for details

Quality Control

Our 3'-Azido-2',3'-Dideoxy-Thymidine-5'-Monophosphate, Sodium Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research and pharmaceutical intermediate applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP principles where applicable, and our quality control protocols are designed to meet the stringent requirements of the pharmaceutical development supply chain.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere for long-term stability. This compound is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.