Description

Salicylacyl Glucuronide is a key glucuronide metabolite of salicylic acid derivatives, representing a significant phase II biotransformation product. This compound is essential for researchers and manufacturers requiring a high-purity reference standard or intermediate for metabolic and pharmacokinetic studies. It is primarily utilized in pharmaceutical R&D, analytical chemistry, and the development of advanced drug delivery systems.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quantification and validation of salicylate metabolites in bioanalytical methods (HPLC, LC-MS/MS).
• Drug Metabolism & Pharmacokinetics (DMPK): Critical for in vitro and in vivo studies to understand the glucuronidation pathway, metabolic stability, and clearance mechanisms of salicylate-based drugs.
• Toxicology Research: Employed in studies investigating the detoxification pathways and potential bioaccumulation of phenolic compounds.
• Enzyme Activity Assays: Serves as a specific substrate for studying the activity and kinetics of UDP-glucuronosyltransferase (UGT) enzymes.
• Biochemical Intermediate: Used in the synthesis of more complex conjugated molecules for targeted research applications.
• Diagnostic Development: Potential use in developing diagnostic kits or assays for monitoring drug metabolism profiles.

Basic Information

Product Name	Salicylacyl Glucuronide
CAS No.	29315-53-5
Molecular Formula	C15H16O9
Molecular Weight	340.28 g/mol
Synonyms	Salicyluric Acid Glucuronide; 2-Hydroxyhippuric Acid Glucuronide; O-Hydroxyhippuric Acid Glucuronide; Salicylacyl-β-D-Glucuronide; 2-[(2-Hydroxybenzoyl)amino]acetic acid β-D-glucopyranosiduronic acid; SA-GLU; Salicyloyl Glucuronide
EINECS	Contact for details

Quality Control

Our Salicylacyl Glucuronide is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for demanding research applications. Each lot undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.