Description

Uridine Diphosphate n-Acetyl-D-Glucosamine, [Glucosamine-14C(U)] is a radiolabeled nucleotide sugar derivative essential for studying glycosylation pathways and carbohydrate metabolism. This compound serves as a critical tracer and substrate in enzymatic assays, enabling precise tracking of biochemical reactions in complex biological systems. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on glycobiology, metabolic research, and drug discovery.

Application

• Glycosyltransferase Assays: Acts as a radiolabeled donor substrate for studying the activity and kinetics of specific glycosyltransferases.
• Metabolic Pathway Tracing: Used in in vitro and cell-based studies to trace the incorporation of N-acetylglucosamine into glycoproteins, proteoglycans, and other glycoconjugates.
• Enzyme Characterization: Essential for the identification, purification, and functional analysis of enzymes involved in nucleotide-sugar metabolism.
• Drug Discovery & Screening: Employed in high-throughput screening (HTS) platforms to identify inhibitors or modulators of glycosylation enzymes as potential therapeutic targets.
• Biochemical Research: Supports fundamental research in cell biology, immunology, and developmental biology related to carbohydrate-mediated processes.
• Quality Control Reference: Can serve as a reference standard in analytical laboratories for method development and validation.

Basic Information

Product Name	Uridine Diphosphate n-Acetyl-D-Glucosamine, [Glucosamine-14C(U)]
CAS No.	28508-02-3
Molecular Formula	C17H27N3O17P2 (with 14C label)
Molecular Weight	Approx. 607.36 g/mol (unlabeled)
Synonyms	UDP-GlcNAc, [14C(U)]; UDP-N-acetyl-D-glucosamine, [Glucosamine-14C(U)]; Uridine 5'-(trihydrogen diphosphate) P'→5'-ester with N-acetyl-D-glucosamine, [14C(U)]; UDP-N-acetylglucosamine-14C; 14C-labeled UDP-GlcNAc; Uridine diphospho-N-acetylglucosamine-14C; β-Nicotinamide Adenine Dinucleotide, oxidized form
EINECS	Contact for details

Quality Control

Every batch of our radiolabeled biochemicals is produced and analyzed under stringent quality control protocols to ensure high specific activity, radiochemical purity, and chemical stability. Analytical methods including HPLC (with radiometric detection), TLC, and NMR are employed for comprehensive characterization. A detailed Certificate of Analysis (COA), specifying specific activity, purity, and solvent information, is provided with each shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C. This product is hygroscopic (moisture-sensitive). For long-term storage, solutions should be aliquoted to avoid repeated freeze-thaw cycles. Follow all applicable laboratory safety and radioactive material handling guidelines.

Specification

Item	Specification
Appearance	White to off-white solid or solution (as specified)
Identification (HPLC)	Conforms to reference standard
Radiochemical Purity	≥ 95%
Chemical Purity (HPLC)	≥ 90%
Specific Activity	Contact for details (mCi/mmol)
Solvent (if supplied as solution)	Specified on COA (e.g., Water, Ethanol:Water)
Concentration	As specified on COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.