Description

3-Iodo-5-Trifluoromethylbenzoic Acid is a high-value, multi-functional aromatic building block characterized by its trifluoromethyl and iodine substituents. This compound is essential for introducing both lipophilicity and a versatile halogen handle into target molecules, enabling advanced synthetic transformations. It is primarily sought after by research chemists and process development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and liquid crystals with unique electronic or optical properties.
• Cross-Coupling Reactions: The iodine atom is an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form biaryl and other conjugated structures.
• Fluorine Chemistry: An important reagent for studying structure-activity relationships (SAR) in medicinal chemistry due to the influence of the trifluoromethyl group on potency and pharmacokinetics.
• Chemical Biology: Utilized as a probe or labeling agent in biochemical research, leveraging the iodine for radio-labeling or further derivatization.

Basic Information

Product Name	3-Iodo-5-Trifluoromethylbenzoic Acid
CAS No.	28186-62-1
Molecular Formula	C8H4F3IO2
Molecular Weight	316.02 g/mol
Synonyms	5-(Trifluoromethyl)-3-iodobenzoic Acid; 3-Iodo-5-(trifluoromethyl)benzoic Acid; Benzoic acid, 3-iodo-5-(trifluoromethyl)-; m-Iodo-α,α,α-trifluoro-m-toluic Acid
EINECS	Contact for details

Quality Control

Our 3-Iodo-5-Trifluoromethylbenzoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and organic solvents. The compound is light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.