Description

Xanthine-2-14C is a carbon-14 labeled derivative of xanthine, a purine base fundamental to nucleic acid biochemistry. This radiolabeled compound is essential for high-sensitivity metabolic and pharmacokinetic studies, enabling precise tracking of purine pathways. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, biotechnology, and life science sectors, particularly for investigating drug metabolism, nucleotide synthesis, and related biochemical mechanisms.

Application

• Tracer Studies in Drug Metabolism and Pharmacokinetics (DMPK): Used as a radiolabeled tracer to study the absorption, distribution, metabolism, and excretion (ADME) of purine-based pharmaceuticals.
• Biochemical Pathway Analysis: Enables the elucidation of purine catabolism and salvage pathways in cellular and in vivo systems.
• Enzyme Activity Assays: Serves as a substrate for studying the activity of enzymes like xanthine oxidase and other purine-metabolizing enzymes.
• Nucleic Acid Research: Used in research exploring the turnover and metabolism of RNA and DNA precursors.
• Quality Control & Reference Standard: Acts as an internal standard or reference material in analytical methods such as LC-MS for quantifying xanthine and its metabolites.
• Toxicological Studies: Applied in research to understand the metabolic fate and potential toxicity of purine analogs.

Basic Information

Product Name	Xanthine-2-14C
CAS No.	27870-87-7
Molecular Formula	C₅H₄¹⁴CN₄O₂
Molecular Weight	Contact for details
Synonyms	1H-Purine-2,6-dione-2-14C, 3,7-dihydro-; 2,6-Dihydroxypurine-2-14C; 3,7-Dihydropurine-2,6-dione-2-14C; Xanthine-2-¹⁴C; [2-14C]Xanthine; Purine-2,6-dione-2-14C, 3,7-dihydro-; 1H-Purine-2,6(3H,7H)-dione-2-14C
EINECS	Contact for details

Quality Control

Our Xanthine-2-14C is manufactured and handled under strict quality systems to ensure high chemical and radiochemical purity. Each batch is analyzed to confirm identity, purity, and specific activity. A comprehensive Certificate of Analysis (COA) is provided, detailing results from analytical techniques including HPLC, NMR, and mass spectrometry. We adhere to relevant GLP (Good Laboratory Practice) standards for research chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures (typically 2-8°C or as specified on the label) in a dedicated, well-ventilated area for radioactive materials. This product is hygroscopic (moisture-sensitive); ensure containers are sealed after each use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR/NMR)	Conforms to structure
Purity (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	Contact for details (mCi/mmol)
Solvent (if supplied as solution)	Specified on label

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.