Description

Methyl (R)-2-Hydroxy-3-Phenylpropionate is a high-purity chiral intermediate, specifically the (R)-enantiomer of the methyl ester of 2-hydroxy-3-phenylpropionic acid. This compound matters as a critical building block for the synthesis of optically active pharmaceuticals and fine chemicals, where stereochemical purity is paramount for efficacy and safety. It is primarily needed by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for developing chiral active pharmaceutical ingredients (APIs), fragrances, and advanced materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of angiotensin-converting enzyme (ACE) inhibitors, β-blockers, and other enantiomerically pure drugs.
• Agrochemical Synthesis: Used in the production of chiral pesticides and herbicides where specific stereochemistry enhances biological activity and reduces environmental impact.
• Flavor and Fragrance Industry: Serves as a precursor for creating stereospecific aroma compounds and flavoring agents.
• Asymmetric Catalysis: Employed as a ligand precursor or a chiral auxiliary in asymmetric synthesis to induce stereoselectivity.
• Academic and R&D: A valuable reagent for methodological development in organic chemistry and medicinal chemistry research.
• Fine Chemical Production: Used in the manufacture of other high-value chiral esters, acids, and alcohols for various industrial applications.

Basic Information

Product Name	Methyl (R)-2-Hydroxy-3-Phenylpropionate
CAS No.	27000-00-6
Molecular Formula	C10H12O3
Molecular Weight	180.20 g/mol
Synonyms	(R)-Methyl 2-Hydroxy-3-phenylpropanoate; (R)-Methyl 2-Hydroxy-3-phenylpropionate; Methyl (R)-(-)-2-Hydroxy-3-phenylpropionate; (R)-2-Hydroxy-3-phenylpropionic acid methyl ester; (R)-HPPA methyl ester; (R)-Mandelic acid β-methyl ester; L-HPPA methyl ester (common); (R)-Phenyl lactic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl (R)-2-Hydroxy-3-Phenylpropionate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for pharmaceutical and research applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong alkalis and incompatible organic solvents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Specific Rotation [α]	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.