Description

Lofepramine Hydrochloride CAS NO 26786-32-3 is a tricyclic antidepressant (TCA) compound, primarily utilized as a key active pharmaceutical ingredient (API). It is valued for its established efficacy in the treatment of depressive disorders, offering a critical component for pharmaceutical manufacturing. This product is essential for pharmaceutical companies, research institutions, and contract development and manufacturing organizations (CDMOs) involved in the production of neuropsychiatric medications.

Application

• Pharmaceutical API: Primary use as the active ingredient in antidepressant formulations.
• Reference Standard: Serves as a high-purity standard for analytical method development and quality control in laboratories.
• Clinical Research: Used in preclinical and clinical studies investigating treatments for major depressive disorder.
• Generic Drug Manufacturing: A critical raw material for the production of generic antidepressant medications.
• Biochemical Research: Employed in studies of neurotransmitter reuptake inhibition mechanisms and psychopharmacology.
• Formulation Development: Used in R&D for developing new dosage forms such as tablets or capsules.

Basic Information

Product Name	Lofepramine Hydrochloride
CAS No.	26786-32-3
Molecular Formula	C₂₆H₂₇ClN₂O•HCl
Molecular Weight	455.42 g/mol
Synonyms	Lofepramine HCl; Gamanil; Emdalen; Tymelyt; 3-Chloro-5-[3-(dimethylamino)propyl]-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride; N-(3-Chloro-10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N',N'-dimethylpropane-1,3-diamine hydrochloride; NSC 113195
EINECS	Contact for details

Quality Control

Our Lofepramine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.