Description

21,25-Dihydroxycholecalciferol is a key metabolite and synthetic analog of Vitamin D3, playing a crucial role in calcium and phosphate homeostasis. This high-purity compound is essential for advanced research and development in endocrinology and metabolic bone disease studies. It serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate for manufacturers in the pharmaceutical and life science sectors.

Application

• Pharmaceutical Research & Development: As a reference standard and key intermediate in the synthesis of novel Vitamin D analogs and therapeutic agents targeting bone metabolism.
• Metabolic Studies: Used in biochemical and pharmacological research to investigate the Vitamin D endocrine system, calcium regulation, and cell differentiation.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as a critical building block in the production of specialized pharmaceuticals for treating conditions like osteoporosis, psoriasis, and secondary hyperparathyroidism.
• Analytical & Quality Control: Employed as a certified reference material (CRM) for method development, validation, and assay calibration in HPLC and LC-MS systems.
• Nutritional Science: Investigated for its role in dietary supplements and fortified foods aimed at improving bone health and immune function.

Basic Information

Product Name	21,25-Dihydroxycholecalciferol
CAS No.	26369-40-4
Molecular Formula	C₂₇H₄₄O₃
Molecular Weight	416.64 g/mol
Synonyms	21,25-Dihydroxyvitamin D3; 21,25-Dihydroxycholecalciferol; 21,25(OH)₂D₃; 21,25-Dihydroxycolecalciferol; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-3β,21,25-triol; 21,25-Dihydroxy Vitamin D3; 1α,25-Dihydroxyvitamin D3 21,25-diol (related metabolite)
EINECS	Contact for details

Quality Control

Our 21,25-Dihydroxycholecalciferol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements for research and pharmaceutical use. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) or as specified on the label or COA. This product is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep the container tightly sealed in a dry and cool place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.