Description

D-Leucine, [1-14 C] CAS NO 26011-27-8 is a carbon-14 labeled isotopologue of the non-proteinogenic amino acid D-leucine, specifically labeled at the 1-carbon position. This compound is an essential tool for advanced metabolic and pharmacokinetic research, enabling precise tracking and quantification in biological systems. It is primarily utilized by researchers and scientists in the pharmaceutical, biotechnology, and agrochemical industries for tracer studies, drug metabolism and disposition (DMPK) analysis, and biochemical pathway investigation.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiolabeled tracer to study the absorption, distribution, metabolism, and excretion (ADME) of new chemical entities and pharmaceutical compounds.
• Biochemical Pathway Analysis: Enables the elucidation of metabolic pathways involving branched-chain amino acids, particularly in studies of leucine metabolism and its role in various physiological and disease states.
• Proteomics and Biomarker Research: Serves as a stable isotope-labeled internal standard in mass spectrometry-based quantitative proteomics and metabolomics for accurate biomarker discovery and validation.
• Agricultural Chemical Research: Applied in environmental fate studies and metabolism research of agrochemicals in plants and soil systems.
• In-vitro Diagnostic (IVD) Development: Used in the development and calibration of diagnostic assays and kits that require high-specificity labeled compounds.
• Medical Research: Facilitates research into metabolic disorders, such as maple syrup urine disease (MSUD), and the study of muscle protein synthesis and degradation.

Basic Information

Product Name	D-Leucine, [1-14 C]
CAS No.	26011-27-8
Molecular Formula	C6H1314CNO2
Molecular Weight	Contact for details
Synonyms	(2R)-2-Amino-4-methyl[1-14C]pentanoic acid; D-(-)-Leucine-1-14C; (R)-2-Amino-4-methyl[1-14C]pentanoic acid; (R)-Leucine-1-14C; D-Leucine-1-Carbon-14; D-Leucine (1-14C); Carbon-14 Labeled D-Leucine; Radiolabeled D-Leucine
EINECS	Contact for details

Quality Control

Our D-Leucine, [1-14 C] is manufactured under strict quality systems to ensure the highest standards of radiochemical purity, chemical purity, and specific activity required for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing critical parameters such as radiochemical purity (by HPLC), chemical purity, specific activity, and solvent content. We adhere to relevant guidelines for the handling and documentation of radioactive materials to ensure traceability and reliability for your research.

Storage

Preserve in a tightly closed container, protected from light. Store at recommended temperatures (typically 2-8°C or as specified on the label) to maintain stability. This product is hygroscopic (moisture-sensitive); ensure the container is sealed in a dry environment to prevent degradation. For long-term storage, consider conditions under an inert atmosphere. Store in accordance with all local, national, and international regulations for radioactive materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98% (chemical purity)
Radiochemical Purity (HPLC)	≥ 97%
Specific Activity	Contact for details (mCi/mmol)
Solvent Content (Residual Solvents)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.